LOW-FREQUENCY STIMULATION OF THE LOCUS COERULEUS REDUCES REGIONAL CEREBRAL BLOOD-FLOW IN THE SPINALIZED CAT
LOW-FREQUENCY STIMULATION OF THE LOCUS COERULEUS REDUCES REGIONAL CEREBRAL BLOOD-FLOW IN THE SPINALIZED CAT
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DOI：
10.1016/0006-8993(89)91537-0
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发表时间：
1989-01-02
期刊：
影响因子：
2.9
通讯作者：
DUCKWORTH, JW
中科院分区：
文献类型：
--
作者：
GOADSBY, PJ;DUCKWORTH, JW
研究了在低频（15/s）和高频（50/s）电刺激α-纹状体中的蓝斑（LC）期间的局部脑血流（RCBF）。使用自由扩散示踪剂[14 C]碘安替比林和局部脑解剖法对氯醛糖麻醉的猫进行了研究。在C1/C2水平进行脊髓化的动物中测定反应，以消除脑桥刺激的全身效应，例如血压和心率的改变。脊髓化本身并不改变静息RCBF或对高碳酸血症的反应性。低频刺激减少皮质、基底节和胼胝体白色物质的局部脑血流量。RCBF的减少在枕叶皮质最大（35%），而在丘中观察到变化。在高频刺激的任何脑区均未观察到变化。这种脑干效应对脑血流的病理状态，如中风和偏头痛的相关性进行了讨论。
Regional cerebral blood flow (RCBF) was studied during low frequency (15/s) and high frequency (50/s) electrical stimulation of the locus coeruleus (LC) in the .alpha.-chloralose-anesthetized cat using the freely diffusible tracer [14C]iodoantipyrine and regional brain dissection. The responses were determined in animals spinalized at the C1/C2 level to eliminate systemic effects of pontine stimulation such as alterations in blood pressure and heart rate. The spinalization, itself, did not alter resting RCBF or reactivity to hypercapnia. Low frequency stimulation reduced regional cerebral blood flow in the cortex, basal ganglia and white matter of the corpus callosum. The reductions in RCBF were maximal (35%) in the occipital cortex whereas to changes were seen in the colliculi. No changes were seen in any brain areas with high frequency stimulation. The relevance of this brainstem effect on cerebral blood flow to pathological states such as stroke and migraine is discussed.