Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods.
Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods.
复制标题
胞二磷胆碱会影响食欲和皮质边缘对高热量食物图像的反应。
DOI：
10.1002/eat.20658
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Yurgelun-Todd,DeborahA
中科院分区：
文献类型：
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作者：
Killgore,WilliamDS;Ross,AmyJ;Kamiya,Toshikazu;Kawada,Yoko;Renshaw,PerryF;Yurgelun-Todd,DeborahA
胞苷-5 ′-二磷酸胆碱（胞磷胆碱）具有多种认知增强，神经保护和神经再生特性。在可卡因成瘾者中，胞磷胆碱已被证明可以增加大脑多巴胺水平并减少渴望。这种化合物对食欲、食物渴望和大脑对食物反应的影响尚不清楚。（500 mg/天vs 2，000 mg/天）持续6周，使用功能性磁共振成像（fMRI）观察食欲等级、体重和皮质边缘系统对高热量食物图像的反应变化。尽管观察到2，000 mg/天剂量组的食欲评分显著下降，但体重状况无显著变化。高剂量组还显示杏仁核、杏仁核和外侧眶额皮质内对食物刺激的功能性脑反应显著增加。在这些地区增加激活与食欲ratings.DiscussionThese初步研究结果表明，胞磷胆碱在调节食欲的潜在用途下降，但需要进一步的研究。© 2009年由Wiley Periodicals，Inc.国际饮食失调杂志2010
ObjectiveCytidine‐5′‐diphosphocholine (citicoline) has a variety of cognitive enhancing, neuroprotective, and neuroregenerative properties. In cocaine‐addicted individuals, citicoline has been shown to increase brain dopamine levels and reduce cravings. The effects of this compound on appetite, food cravings, and brain responses to food are unknown.MethodWe compared the effects of treatment with Cognizin® citicoline (500 mg/day versus 2,000 mg/day) for 6 weeks on changes in appetite ratings, weight, and cortico‐limbic responses to images of high‐calorie foods using functional magnetic resonance imaging (fMRI).ResultsAfter 6 weeks, there was no significant change in weight status, although significant declines in appetite ratings were observed for the 2,000 mg/day group. The higher dose group also showed significant increases in functional brain responses to food stimuli within the amygdala, insula, and lateral orbitofrontal cortex. Increased activation in these regions correlated with declines in appetite ratings.DiscussionThese preliminary findings suggest a potential usefulness of citicoline in modulating appetite, but further research is warranted. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010