Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections
Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections
复制标题
DOI：
10.1128/iai.67.6.3128-3132.1999
复制
发表时间：
1999-06-01
影响因子：
3.1
通讯作者：
De Baetselier, P
中科院分区：
文献类型：
--
作者：
Magez, S;Radwanska, M;De Baetselier, P
为了评价在实验性布氏锥虫感染过程中肿瘤坏死因子α（TNF-α）在宿主-寄生虫相互关系中的潜在作用，用多形性T.在TNF-α（-/-）小鼠中，与野生型小鼠中记录的峰值水平相比，寄生虫血症的峰值水平显著增加。寄生虫负荷的增加并不反映清除效率或T产生的差异。布鲁氏菌特异性免疫球蛋白M（IgM）和IgG抗体。锥虫介导的免疫病理学特征，如淋巴结相关的免疫抑制和脂多糖超敏反应，被发现在感染的TNF-α（-/-）小鼠中大大减少。这些结果表明，在锥虫感染期间，TNF-α是参与寄生虫血症控制和感染相关病理的关键介质。
In order to evaluate during experimental Trypanosoma br brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha(-/-)) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites, In the TNF-alpha(-/-) mice, the peak levels of parasitemia were strongly increased compared to the peak levels recorded in wild-type mice. The increased parasite burden did not reflect differences in clearance efficacy or in production of T. brucei-specific immunoglobulin M (IgM) and IgG antibodies. Trypanosome-mediated immunopathological features, such as lymph node-associated immunosuppression and lipopolysaccharide hypersensitivity, were found to be greatly reduced in infected TNF-alpha(-/-) mice. These results demonstrate that, during trypanosome infections, TNF-alpha is a key mediator involved in both parasitemia control and infection-associated pathology.