Immunological alterations in patients with chronic prostatitis/chronic pelvic pain syndrome and experimental autoimmune prostatitis model: A systematic review and meta-analysis
Immunological alterations in patients with chronic prostatitis/chronic pelvic pain syndrome and experimental autoimmune prostatitis model: A systematic review and meta-analysis
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慢性前列腺炎/慢性盆腔疼痛综合征和实验性自身免疫性前列腺炎模型患者的免疫学改变：系统评价和荟萃分析。
DOI：
10.1016/j.cyto.2021.155440
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发表时间：
2021-02-04
期刊：
影响因子：
3.8
通讯作者：
Liang, Chaozhao
中科院分区：
文献类型：
--
作者：
Chen, Lei;Bian, Zichen;Liang, Chaozhao
背景：慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）是泌尿外科门诊最常见的疾病之一，其病因不明且缺乏有效的治疗方法，困扰着许多患者。最近，支持CP/CPPS的免疫学改变被广泛研究。方法：通过PubMed、Web of Science、Cochrane图书馆和EMBASE数据库检索截至2020年4月10日的关于CP/CPPS患者和实验性自身免疫性前列腺炎（EAP）模型中免疫介质的原始文章。计算标准化平均差异（SMD）来总结组间免疫介质水平的差异。漏斗图，贝格？什么是漏斗图，艾格？采用S回归检验和敏感性分析来确定和可视化我们研究结果的稳定性。结果：meta分析共纳入34项原始研究，其中CP/CPPS患者研究24项，EAP模型研究10项。我们发现TNF-？, il - 1 ?在CP/CPPS患者和EAP模型的大多数样本中，IL-6和IL-8是升高的四种免疫介质。校正发表偏倚分析显示不存在发表偏倚，敏感性分析显示结果稳定。结论：免疫应答通过促进前列腺内炎症在CP/CPPS发病过程中发挥重要作用。我们的发现为CP/CPPS患者提供了潜在的诊断和治疗靶点。
Background: As one of the most common conditions in urological outpatients, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) puzzles many individuals because of its unclear etiology and lack of effective treat-ment. Recently, immunological alterations underpinning CP/CPPS have been extensively investigated. Methods: The PubMed, Web of Science, Cochrane library, and EMBASE databases were used to search original articles on immune mediators in patients with CP/CPPS and in experimental autoimmune prostatitis (EAP) models through April 10, 2020. Standardized mean differences (SMD) were calculated to summarize the dif-ferences in immune mediator levels between groups. Funnel plot, Begg?s funnel plot, Egger?s regression test, and the sensitivity analysis were applied to determine and visualize the stability of our findings. Results: A total of 34 original studies were included in the meta-analysis, including 24 studies on patients with CP/CPPS and 10 studies on EAP models. We found that TNF-?, IL-1?, IL-6, and IL-8 were the four immune mediators that elevated in most of the samples derived from patients with CP/CPPS and the EAP models. The adjusted publication bias analysis indicated that publication bias was not existed, and the sensitivity analyses showed that the results were stable. Conclusions: Immune responses play significant roles during the pathogenesis of CP/CPPS by promoting intra-prostatic inflammation. Our findings provide potential diagnostic and therapeutic targets for CP/CPPS patients.