PRACTICAL CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF PROPRANOLOL
PRACTICAL CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF PROPRANOLOL
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DOI：
10.1021/jo00018a032
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发表时间：
1991-08-30
影响因子：
3.6
通讯作者：
BANERJI, AA
中科院分区：
文献类型：
--
作者：
BEVINAKATTI, HS;BANERJI, AA
以1-萘酚和环氧氯丙烷为原料，以高的光学产率和化学产率合成了（R）-和（S）-普萘洛尔。研究了关键中间体1-氯-3-（1-萘氧基）-2-丙醇及其O-乙酰基酯1-氯-2-乙酰氧基-3-（1-萘氧基）丙烷的脂肪酶催化动力学拆分。
Synthesis of (R)- and (S)-propranolol in high optical and chemical yields was achieved starting from 1-naphthol and epichlorohydrin. Lipase-catalyzed kinetic resolution of key intermediates 1-chloro-3-(1-naphthyloxy)-2-propanol and its O-acetyl ester 1-chloro-2-acetoxy-3-(1-naphthyloxy) propane was studied using four different approaches.