Diphenhydramine in Insomniac Family Practice Patients: A Double‐Blind Study
Diphenhydramine in Insomniac Family Practice Patients: A Double‐Blind Study
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苯海拉明在家庭医生失眠患者中的应用：一项双盲研究
DOI：
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发表时间：
1983
影响因子：
2.9
通讯作者：
R. Weinstock
中科院分区：
文献类型：
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作者：
K. Rickels;R. Morris;H. Newman;H. Rosenfeld;Herbert Schiller;R. Weinstock
摘要：111名轻至中度失眠症患者参加了一项双盲、安慰剂对照研究，以确定苯海拉明作为非处方药(OTC)助眠剂的疗效。采用了为期两周的交叉设计，所有患者均接受苯海拉明和安慰剂治疗，各为期一周。苯海拉明每日剂量为睡前50毫克。结果表明，苯海拉明改善包括睡眠潜伏期在内的各种睡眠参数的程度明显高于安慰剂。此外，服用苯海拉明的患者报告第二天早上感觉更休息，尽管经历了更多的副作用，但患者更喜欢苯海拉明药物而不是安慰剂。因此，这项研究支持使用50毫克苯海拉明作为非处方药睡眠辅助剂，用于治疗暂时性轻度至中度失眠。
Abstract: One hundred eleven mildly to moderately insomniac patients participated in a double‐blind, placebo‐controlled study to establish the efficacy of diphenhydramine as an over‐the‐counter (OTC) sleep aid. A two‐week crossover design was employed in which all patients received both diphenhydramine and placebo for one week each. The daily diphenhydramine dose was 50 mg at bedtime. Results obtained indicate that diphenhydramine improved various sleep parameters, including sleep latency, to a significantly higher degree than did placebo. In addition, patients on diphenhydramine reported feeling more restful the following morning and patients preferred the diphenhydramine drug to placebo despite experiencing more side effects. This study thus supports the use of 50 mg diphenhydramine as an OTC sleep aid in the treatment of temporary mild to moderate insomnia.