Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
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DOI：
10.1016/s0140-6736(10)61924-1
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发表时间：
2010-11-13
期刊：
影响因子：
168.9
通讯作者：
White, Nicholas J.
中科院分区：
文献类型：
--
作者：
Dondorp, Arjen M.;Fanello, Caterina I.;White, Nicholas J.
严重疟疾是儿童死亡的主要原因，在撒哈拉以南非洲，奎宁仍然是公认的治疗选择，尽管亚洲的证据表明青蒿琥酯与较低的死亡率有关，但我们在非洲严重疟疾儿童中比较了青蒿琥酯或奎宁的肠外治疗方法。在9个非洲国家，儿童（
Background Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub Saharan Africa Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality We compared parenteral treatment with either artesunate or quinine in African children with severe malariaMethods This open label randomised trial was undertaken in 11 centres in nine African countries Children (