High throughput membrane emulsification using a single-pass annular flow crossflow membrane
High throughput membrane emulsification using a single-pass annular flow crossflow membrane
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DOI：
10.1002/aic.16958
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发表时间：
2020-03-30
期刊：
影响因子：
3.7
通讯作者：
Trotter, Samuel
中科院分区：
文献类型：
--
作者：
Holdich, Richard;Dragosavac, Marijana;Trotter, Samuel
膜乳化技术有可能彻底改变均匀乳液和分散体的节能生产，涉及从药物活性成分控释颗粒到快速消费品的各个领域。开发了一种新型的高度稳健的单程连续相错流系统，从单个100 mm长的膜管提供高达40%vol/vol的分散相浓度和高达5，730 L m（-2）hr（-1）的分散相通量。两个水包油系统（植物油和聚己内酯溶解在二氯甲烷）和一个水包油系统（硅酸钠溶液）的广泛结果的报告，分别使用亲水和疏水膜。数学模型经过验证，能够对工艺进行全面的工程分析，包括预测的液滴尺寸、膜压降和分散体生产的能量需求。表面活性剂消耗，孔利用率，和液滴在膜表面的相互作用进行了研究，提供了一个全面的分析的能力，新的环状流膜乳化高通量乳液的产生。
Membrane emulsification has the potential to revolutionize the energy-efficient production of uniform emulsions and dispersions, relevant to diverse fields from pharmaceutical active ingredient controlled release particles to Fast Moving Consumer Goods. A novel highly robust single-pass continuous phase crossflow system has been developed providing dispersed phase concentrations up to 40% vol/vol and dispersed phase fluxes up to 5,730 L m(-2) hr(-1), from a single 100 mm long membrane tube. Extensive results of two oil-in-water systems (vegetable oil and PolyCaproLactone dissolved in DiChloroMethane) and one water-in-oil system (sodium silicate solution) are reported, using hydrophilic and hydrophobic membranes respectively. Mathematical models are validated enabling comprehensive engineering analysis of processes including predicted droplet size, membrane pressure drops, and energy requirement for dispersion production. Surfactant depletion, pore utilization, and droplet interaction at the membrane surface were investigated to provide a comprehensive analysis of the capabilities of novel annular-flow membrane emulsification for high throughput emulsion generation.