Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein
Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein
复制标题
DOI：
10.1016/s0140-6736(00)05252-1
复制
发表时间：
2001-07-07
期刊：
影响因子：
168.9
通讯作者：
Hawkins, PN
中科院分区：
文献类型：
--
作者：
Gillmore, JD;Lovat, LB;Hawkins, PN
背景：反应性系统性（AA，继发性）淀粉样变性发生在慢性炎症性疾病中，大多数患者表现为肾病。淀粉样原纤维来源于循环急性期反应物血清淀粉样A蛋白（SAA），但fib，il前体蛋白，淀粉样负荷，AA和其他类型淀粉样变性的临床结果尚不清楚。方法我们前瞻性研究了12- 80例系统性AA型淀粉样变性患者，每月测定血清SAA浓度，每年通过血清淀粉样蛋白P成分放射成像评估内脏淀粉样蛋白沉积，为期117个月。尽可能积极地治疗潜在的炎症性疾病。发现42名患者中有25名淀粉样蛋白沉积消退，其平均SAA值在参考范围内（
Background Reactive systemic (AA, secondary) amyloidosis occurs in chronic inflammatory diseases, and most patients present with nephropathy. The amyloid fibrils are derived from the circulating acute-phase reactant serum amyloid A protein (SAA), but the relation between production of fib,il precursor protein, amyloid load, and clinical outcome in AA and other types of amyloidosis is unclear.Methods We studied amyloidotic organ function and survival prospectively for 12-117 months in 80 patients with systemic AA amyloidosis in whom serum SAA concentration was measured monthly and visceral amyloid deposits were assessed annually by serum amyloid P component scintigraphy. Underlying inflammatory diseases were treated as vigorously as possible.Findings Amyloid deposits regressed in 25 of 42 patients whose median SAA values were within the reference range (