A novel azopyridine-based Ru(II) complex with GSH-responsive DNA photobinding ability.

A novel azopyridine-based Ru(II) complex with GSH-responsive DNA photobinding ability.
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DOI：
10.1039/c5cc03291a
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发表时间：
2015-06
期刊：
Chemical communications
影响因子：
4.9
通讯作者：
Qian Zhou;Yue Zheng;Tian Wang;Yongjie Chen;Ke Li;Yang Zhang;Chao Li;Yuan-jun Hou;Xuesong Wang
Qian Zhou;Yue Zheng;Tian Wang;Yongjie Chen;Ke Li;Yang Zhang;Chao Li;Yuan-jun Hou;Xuesong Wang
中科院分区：
化学2区
文献类型：
--
作者：
Qian Zhou;Yue Zheng;Tian Wang;Yongjie Chen;Ke Li;Yang Zhang;Chao Li;Yuan-jun Hou;Xuesong Wang

文献摘要

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A novel azopyridine-based Ru(II) complex [Ru(bpy)2(L1)2](2+) (bpy = 2,2'-bipyridine, L1 = 4,4'-azopyridine) was designed and synthesized as a potential glutathione (GSH)-responsive photoactivated chemotherapy (PACT) agent, the DNA covalent binding capability of which can only be activated after GSH reduction and visible light irradiation.