Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study.
Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study.
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轮班工作和亚临床心血管疾病的生物标志物：BCOPS 研究。
DOI：
10.1097/jom.0000000000001541
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发表时间：
2019
影响因子：
3.2
通讯作者：
Violanti,JohnM
中科院分区：
文献类型：
--
作者：
Holst,MeghanM;Wirth,MichaelD;Mnatsakanova,Anna;Burch,JamesB;Charles,LuendaE;Tinney-Zara,Cathy;Fekedulegn,Desta;Andrew,MichaelE;Hartley,TaraA;Violanti,JohnM
目的：评估倒班与亚临床心血管疾病生物标志物的关系，并检查体重指数（BMI）在警察队列中的调节作用。方法：在白班、晚班或夜班的警官中进行了横断面分析。通过方差/协方差分析与炎症生物标志物进行比较，并通过BMI进一步分层以评估潜在的效果改变。结果：白班和夜班工人在白细胞、肿瘤坏死因子α和同型半胱氨酸方面存在关联。BMI分层后，与白班相比，BMI大于或等于30 kg/ m2的夜班工人的c反应蛋白（CRP）水平较高。结论：未来的研究将检查这些标志物的前瞻性变化，从而更全面地评估它们与轮班工作的关系。
Objective:To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.Methods:A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.Results:Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30 kg/m 2 versus the day shift.Conclusions:Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.