Mathematical investigation of HBeAg seroclearance
Mathematical investigation of HBeAg seroclearance
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DOI：
10.3934/mbe.2019382
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发表时间：
2019-01-01
影响因子：
2.6
通讯作者：
Ciupe, Stanca M.
中科院分区：
文献类型：
--
作者：
Kadelka, Sarah;Ciupe, Stanca M.
自发或药物诱导的B e抗原丢失被认为是慢性B型肝炎病毒感染疾病进展中的有益事件。提出了宿主内相互作用的数学模型，它提供了深入了解乙型肝炎B e抗体的形成，其对乙型肝炎B e抗原血清清除的影响，以及无反应性细胞毒性免疫反应的逆转。他们预测抗体扩增导致免疫激活和B e肝炎抗原血清清除。在存在和不存在治疗的情况下，抗体扩增和B e抗原血清清除之间的时间的定量显示，有效的短期治疗加速了抗体扩增和B e抗原血清清除之间的时间。这段时间内的每月肝细胞周转可以通过处理增加或减少，这取决于产生的核心启动子或前核心突变病毒的量。这些结果可以为人类干预提供信息。
Spontaneous or drug-induced loss of hepatitis B e antigen is considered a beneficial event in the disease progression of chronic hepatitis B virus infections. Mathematical models of within-host interactions are proposed; which provide insight into hepatitis B e antibody formation, its influence on hepatitis B e antigen seroclearance, and reversion of anergic cytotoxic immune responses. They predict that antibody expansion causes immune activation and hepatitis B e antigen seroclearance. Quantification of the time between antibody expansion and hepatitis B e antigen seroclearance in the presence and absence of treatment shows that potent short-term treatment speeds up the time between antibody expansion and hepatitis B e antigen seroclearance. The monthly hepatocyte turnover during this time can be increased or decreased by treatment depending on the amount of core promoter or precore mutated virus produced. The results can inform human interventions.