Effects of acetazolamide on choroidal blood flow
Effects of acetazolamide on choroidal blood flow
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DOI：
10.1161/01.str.29.5.997
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发表时间：
1998-05-01
期刊：
影响因子：
8.3
通讯作者：
Schmetterer, L
中科院分区：
文献类型：
--
作者：
Dallinger, S;Bobr, B;Schmetterer, L
背景和目的-乙酰唑胺激发试验通常用于研究脑血管反应性。在中枢神经系统中的碳酸酐酶抑制剂的影响的基础上，我们假设，乙酰唑胺也可以增加血流量在人类choroid. Methods，在安慰剂对照，随机，双盲，三向交叉设计，乙酰唑胺（500毫克或1000毫克IV）或安慰剂给药9名健康受试者。每隔15分钟观察一次乙酰唑胺的作用，持续90分钟，用激光干涉测量眼底搏动来评估脉络膜搏动性血流。应用多普勒超声测量眼动脉平均血流速度和阻力指数。在第二项对6名健康受试者的研究中，我们评估了乙酰唑胺（1000 mg IV）对眼内压的影响。结果乙酰唑胺以剂量依赖性方式增加眼底搏动幅度（1000 mg：+33%; 500 mg：+20%; P
Background and Purpose-The acetazolamide provocation test is commonly used to study cerebrovascular vasomotor reactivity. On the basis of the effect of a carbonic anhydrase inhibitor in the central nervous system, we hypothesized that acetazolamide may also increase blood flow in the human choroid.Methods-In a placebo-controlled, randomized, double-blind, three-way crossover design, acetazolamide (500 mg or 1000 mg IV) or placebo was administered to nine healthy subjects. The effect of acetazolamide was studied at 15-minute intervals for 90 minutes, Pulsatile choroidal blood flow was assessed with laser interferometric measurement of fundus pulsation. In addition, mean blood flow velocity and resistive index in the ophthalmic artery were measured with Doppler sonography. In a second study in six healthy subjects, we assessed the effect of acetazolamide (1000 mg IV) on intraocular pressure.Results-Acetazolamide increased fundus pulsation amplitude in a dose-dependent manner (1000 mg: +33%; 500 mg: +20%; P