Decreased plasma antioxidants in schizophrenia
Decreased plasma antioxidants in schizophrenia
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DOI：
10.1159/000077942
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发表时间：
2004-01-01
影响因子：
3.2
通讯作者：
Lee, CU
中科院分区：
文献类型：
--
作者：
Chi-Un, P;Paik, IH;Lee, CU
精神分裂症患者体内抗氧化剂水平出现异常。因此，本研究检测了精神分裂症患者和健康对照组之间的抗氧化剂水平的差异，以及药物初治的首发精神分裂症患者(FSPR)和利培酮治疗的慢性精神分裂症(RCSPR)患者之间的差异。对符合DSM-IV精神分裂症诊断标准的47例FSPR患者、55例慢性精神分裂症患者和68例正常对照的血浆白蛋白、胆红素和尿酸水平进行了测定。精神分裂症患者的白蛋白和胆红素水平显著低于对照组，但FSPR患者和RCSPR患者之间无显著差异。胆红素水平在患者组的阴性亚组中显著降低。这项研究支持这样的假设，即抗氧化剂水平的异常可能与精神分裂症有关。此外，本研究提示，抗氧化剂水平可能与精神分裂症的临床症状和治疗意义有关，特别是阴性症状。版权所有(C)2004 S.Karger AG，巴塞尔。
An aberration in the level of antioxidants has been suggested in schizophrenia. Therefore, this study examined the difference in the antioxidant level between patients with schizophrenia and healthy controls, as well as the difference between the drug-naive schizophrenic patients with a first episode (FSPR) and the risperidone-treated chronic schizophrenia (RCSPR) patients. The plasma albumin, bilirubin and uric acid levels were determined in 47 FSPR and 55 chronic schizophrenia patients who met the DSM-IV criteria for schizophrenia, and in 68 controls. The albumin and bilirubin levels were significantly lower in the schizophrenic patients compared to the controls, although there was no significant difference between the FSPR and RCSPR patients. The bilirubin level was significantly lower in the negative subgroup of the patient group. This study supports the hypothesis that an aberration in the antioxidant levels may be involved in schizophrenia. In addition, this study suggests that the antioxidant level may be associated with the clinical symptomatology as well as the treatment implications in schizophrenia, particularly the negative symptoms. Copyright (C) 2004 S. Karger AG, Basel.