New developments for the detection and treatment of cardiac vasculopathy.
New developments for the detection and treatment of cardiac vasculopathy.
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DOI：
10.1097/hco.0000000000000388
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发表时间：
2017-05
影响因子：
2.3
通讯作者：
Mancini DM
中科院分区：
文献类型：
--
作者：
Clerkin KJ;Ali ZA;Mancini DM
心脏移植物血管病(CAV)是心脏移植后长期存活的主要限制因素。诊断CAV的创新技术已被应用于疾病检测。这篇综述将考察目前临床医生可用于CAV的诊断和治疗方案。与传统的(血管造影术和多巴酚丁胺负荷超声心动图)技术相比，针对CAV(动脉壁增厚和冠状动脉血流减少)的病理生理学的诊断方式提高了诊断的敏感性。预防和治疗CAV的选择有限；然而，在作出更早和更准确的诊断方面取得了进展。需要进一步的研究来确定修改免疫抑制的最佳时间，并研究治疗CAV的新方法。
Cardiac allograft vasculopathy (CAV) is a major limitation to long term survival after heart transplantation. Innovative new techniques to diagnose CAV have been applied to detect disease. This review will examine the current diagnostic and treatment options available to clinicians for CAV. Diagnostic modalities addressing the pathophysiology underlying CAV (arterial wall thickening and decreased coronary blood flow) improve diagnostic sensitivity when compared to traditional (angiography and dobutamine stress echocardiography) techniques. Limited options are available to prevent and treat CAV; however progress has been made in making an earlier and more accurate diagnosis. Future research is needed to identify the optimal time to modify immunosuppression and investigate novel treatments for CAV.