How to make an intestine
How to make an intestine
复制标题
DOI：
10.1242/dev.097386
复制
发表时间：
2014-02-15
期刊：
影响因子：
4.6
通讯作者：
Spence, Jason R.
中科院分区：
文献类型：
--
作者：
Wells, James M.;Spence, Jason R.
随着胃肠道疾病的高患病率，人们对建立人类肠道疾病的体外模型和开发更准确地代表肠道复杂生理学的药物筛选平台产生了极大的兴趣。我们将回顾最近在发育和干细胞生物学方面的进展如何使人们有可能通过定向分化人类多能干细胞在体外产生复杂的，三维的，人类肠道组织。目前，这些技术被用于研究人类发育、疾病的遗传形式、肠道病原体、代谢疾病和癌症。
With the high prevalence of gastrointestinal disorders, there is great interest in establishing in vitro models of human intestinal disease and in developing drug-screening platforms that more accurately represent the complex physiology of the intestine. We will review how recent advances in developmental and stem cell biology have made it possible to generate complex, three-dimensional, human intestinal tissues in vitro through directed differentiation of human pluripotent stem cells. These are currently being used to study human development, genetic forms of disease, intestinal pathogens, metabolic disease and cancer.