CHANGES IN HEMOSTATIC SYSTEM AFTER APPLICATION OF A TOURNIQUET
CHANGES IN HEMOSTATIC SYSTEM AFTER APPLICATION OF A TOURNIQUET
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DOI：
10.1016/s0140-6736(77)92276-0
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发表时间：
1977-01-01
期刊：
影响因子：
168.9
通讯作者：
STIRLING, Y
中科院分区：
文献类型：
--
作者：
KLENERMAN, L;CHAKRABARTI, R;STIRLING, Y
在35例接受常规骨科手术并使用闭塞止血带的患者中，在释放止血带后，体循环中纤维蛋白溶解活性明显升高，持续至少15分钟；这种反应出现在手臂和腿部手术后。与静脉闭塞相关的体循环纤维蛋白溶解活性没有增加。止血带的应用和静脉阻塞都不会导致V或VIII因子、纤维蛋白原或血小板计数的变化。应用完全闭塞止血带可能是预防深静脉血栓形成的一种简单形式，并可避免使用肝素的缺点。
In 35 patients undergoing routine orthopedic operations in which occlusive tourniquets were used there was a pronounced rise in fibrinolytic activity in the systemic circulation which lasted for at least 15 min after the release of the tourniquet; this response was seen after operations on arms and legs. There was no increase in fibrinolytic activity in the systemic circulation associated with venous occlusion. Neither the application of a tourniquet nor venous occlusion resulted in changes in factors V or VIII, fibrinogen, or platelet-count. The application of a completely occlusive tourniquet might be a simple form of prophylaxis against deep-vein thrombosis and would avoid the disadvantages of using heparin.