Embryotoxicity assessment and efficient removal of naphthalene from water by irradiated graphene aerogels.
Embryotoxicity assessment and efficient removal of naphthalene from water by irradiated graphene aerogels.
复制标题
DOI：
10.1016/j.ecoenv.2019.110051
复制
发表时间：
2019-12
影响因子：
6.8
通讯作者：
Yang Liu;J. Bai;H. Yao;Guo Li;Taofeng Zhang;Sirui Li;Luwei Zhang;J. Si;R. Zhou;Hong Zhang-H
中科院分区：
文献类型：
--
作者：
Yang Liu;J. Bai;H. Yao;Guo Li;Taofeng Zhang;Sirui Li;Luwei Zhang;J. Si;R. Zhou;Hong Zhang-H
由于萘对人类的致癌风险，如何将其从水中消除仍然是一个挑战。在本研究中，萘显着增加胚胎死亡率和畸形率，并降低孵化率的斑马鱼，具有高度的发育相似性的人。此外，在萘处理的斑马鱼中发现了显著的多器官毒性。本文采用高能电子束辐照石墨烯气凝胶（伊加），与未辐照的石墨烯气凝胶相比，制备出了更多的褶皱、褶皱、缺陷和对萘的强吸收能力。结果表明，伊加能显著清除胚胎培养液中的萘，并通过恢复心脏功能、减弱细胞凋亡信号、恢复眼的形态结构、降低组织中热休克蛋白70的表达、促进行为能力等途径抑制胚胎毒性，维持组织完整性。同时，伊加对斑马鱼从胚胎到仔鱼的发育没有明显的负面影响。因此，在斑马鱼胚胎发育过程中，萘的毒性降低介导的伊加作为一种先进的策略。
Naphthalene has remained a challenge how to eradicate it from the water because of its carcinogenic risk to humans. In the present study, naphthalene prominently increased the rates of embryonic mortality and malformation, and decreased the hatchability of zebrafish which have a high developmental similarity to humans. Moreover, multiple-organ toxicity were notably found in naphthalene-treated zebrafish. Here, irradiated graphene aerogel (IGA) was successfully prepared from high-energy electron beam to generate more wrinkles, folds, defects and a strong absorption capability for naphthalene, compared with the non-irradiated graphene aerogel. IGA was outstandingly found to remove naphthalene from the embryo culture medium, and subsequently inhibit the embryotoxicity and maintain tissue integrity by restoring cardiac function, attenuating apoptosis signals, recovering eye morphology and structure, reducing expression of heat shock protein 70 in the tissues and promoting behavioral capacity. Meanwhile, no obvious negative impact of IGA was found in the developing zebrafish from embryo to larvae. Consequently, reduction in the toxicity of naphthalene during zebrafish embryogenesis was mediated by IGA as an advanced strategy.