Discriminative-stimulus effects of modafinil in cocaine-trained humans
Discriminative-stimulus effects of modafinil in cocaine-trained humans
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DOI：
10.1016/s0376-8716(02)00082-0
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发表时间：
2002-08-01
影响因子：
4.2
通讯作者：
Wooten, AF
中科院分区：
文献类型：
--
作者：
Rush, CR;Kelly, TH;Wooten, AF
莫达非尼是一种新型兴奋剂，可有效治疗发作性睡病和白天过度嗜睡。体外和体内神经药理学数据表明，莫达非尼的作用机制不同于可卡因和 d-安非他明等典型滥用兴奋剂。在本实验中，六名近期有吸食可卡因历史的人类志愿者学会了辨别 150 毫克口服可卡因盐酸盐。获得辨别力（即连续 4 天正确反应大于或等于 80%）后，对一系列剂量的口服可卡因（50、100 和 150 毫克）、莫达非尼（200、400 和 600 毫克）和安慰剂进行测试，以确定它们是否与 150 毫克可卡因具有相同的辨别刺激和自我报告效应。哌醋甲酯 (60 mg) 和三唑仑 (0.5 mg) 分别作为阳性对照和阴性对照。可卡因和哌醋甲酯，但莫达非尼和三唑仑都不会产生类似可卡因的辨别刺激、受试者评级和心血管效应。本实验的结果表明，人类对可卡因的辨别在药物类别内和药物类别之间具有药理学特异性。 (C) 2002 年，爱思唯尔科学爱尔兰有限公司出版。
Modafinil is a novel stimulant that is effective in the treatment of narcolepsy and excessive daytime sleepiness. In vitro and in vivo neuropharmacological data suggest that the mechanism of action of modafinil is distinct from that of prototypical abused stimulants like cocaine and d-amphetamine. In the present experiment, six human volunteers with recent histories of cocaine use learned to discriminate 150 mg oral cocaine HCL. After acquiring the discrimination (i.e. greater than or equal to 80% correct responding on 4 consecutive days), a range of doses of oral cocaine (50, 100, and 150 mg), modafinil (200, 400, and 600 mg), and placebo were tested to determine if they shared discriminative-stimulus and self-reported effects with 150 mg cocaine. Methylphenidate (60 mg) and triazolam (0.5 mg) were included as positive and negative controls, respectively. Cocaine and methylphenidate, but neither modafinil nor triazolam, produced cocaine-like discriminative-stimulus, subject-rated, and cardiovascular effects. The results of the present experiment suggest that cocaine discrimination in humans is pharmacologically specific within and across drug classes. (C) 2002 Published by Elsevier Science Ireland Ltd.