Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults
Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults
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DOI：
10.1038/s41598-020-72245-7
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发表时间：
2020-09-16
影响因子：
4.6
通讯作者：
Miyachi, Motohiko
中科院分区：
文献类型：
--
作者：
Watanabe, Daiki;Murakami, Haruka;Miyachi, Motohiko
饮食对结直肠癌（CRC）发病率的相对贡献高于其他癌症。动物模型显示，含聚酮合酶（pks（+）E.大肠杆菌）参与CRC的发展。这项横断面研究的目的是检查膳食摄入量与pks（+）E患病率之间的关系。从223名健康日本人的粪便样本中分离出的大肠杆菌。饮食摄入量评估使用以前验证过的ESTA型自我管理的饮食史问卷。pks（+）E.使用从参与者收集的粪便样品和检测pks（+）E.杆菌pks（+）E.大肠埃希菌阳性率为26.9%。校正基线混杂因素后，pks（+）E.大肠杆菌与绿色茶摄入量呈负相关（比值比[OR]，0.59 [95%置信区间（CI）0.30-0.88]/100 g/1，000 kcal增量）和锰（OR，0.43 [95% CI 0.22-0.85]/1 mg/1，000 kcal增量），与男性性别呈正相关（OR，2.27 [95% CI 1.05-4.91]）。虽然需要进一步的研究来验证这些发现，但这些结果为预防CRC提供了潜在的饮食干预措施。
The relative contribution of diet to colorectal cancer (CRC) incidence is higher than that for other cancers. Animal models have revealed that Escherichia coli containing polyketide synthase (pks(+)E. coli) in the gut participates in CRC development. The purpose of this cross-sectional study was to examine the relationship between dietary intake and the prevalence of pks(+)E. coli isolated from the microbiota in faecal samples of 223 healthy Japanese individuals. Dietary intake was assessed using a previously validated brief-type self-administered diet history questionnaire. The prevalence of pks(+)E. coli was evaluated using faecal samples collected from participants and specific primers that detected pks(+)E. coli. The prevalence of pks(+)E. coli was 26.9%. After adjusting for baseline confounders, the prevalence of pks(+)E. coli was negatively associated with the intake of green tea (odds ratio [OR], 0.59 [95% confidence interval (CI) 0.30-0.88] per 100 g/1,000 kcal increment) and manganese (OR, 0.43 [95% CI 0.22-0.85] per 1 mg/1,000 kcal increment) and was positively associated with male sex (OR, 2.27 [95% CI 1.05-4.91]). While futher studies are needed to validate these findings, these results provide insight into potential dietary interventions for the prevention of CRC.