Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors
Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors
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DOI：
10.1016/j.neuropharm.2011.02.002
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发表时间：
2011-06-01
影响因子：
4.7
通讯作者：
Whitaker-Azmitia, Patricia M.
中科院分区：
文献类型：
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作者：
Azmitia, Efrain C.;Singh, Jorawer S.;Whitaker-Azmitia, Patricia M.
自闭症患者血清素转运蛋白结合或色氨酸保留的影像学研究表明，大脑血清素系统下降。然而，使用增加血清素 (5-HT) 水平的药物（特定血清素再摄取抑制剂 (SSRI)）治疗通常会导致症状恶化。在这项研究中，我们检查了许多年龄从 2 岁到 29 岁的自闭症患者和未知诊断对照者死后大脑中对血清素转运蛋白 (5-HTT) 抗体产生免疫反应的 5-HT 轴突。在前脑通路（例如内侧前脑束、终纹和豆状袢）中发现了细的、高度分支的和粗的直纤维。在目标区域（例如苍白球、杏仁核和颞叶皮层）观察到许多免疫反应性曲张细纤维。对所研究的所有年龄段的染色轴突进行形态计量分析表明，自闭症供体的皮质通路和末端区域的血清素轴突数量均有所增加。我们的研究结果提供了形态学证据，在使用血清素增强药物（例如 SSRI 和受体激动剂）治疗自闭症儿童时需要谨慎。本文是题为“神经药理学趋势：纪念埃尔米尼奥·科斯塔”特刊的一部分。 (C) 2011 Elsevier Ltd. 保留所有权利。
Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this study we examined 5-HT axons that were immunoreactive to a serotonin transporter (5-HTT) antibody in a number of postmortem brains from autistic patients and controls with no known diagnosis who ranged in age from 2 to 29 years. Fine, highly branched, and thick straight fibers were found in forebrain pathways (e.g. medial forebrain bundle, stria terminalis and ansa lenticularis). Many immunoreactive varicose fine fibers were seen in target areas (e.g. globus pallidus, amygdala and temporal cortex). Morphometric analysis of the stained axons at all ages studied indicated that the number of serotonin axons was increased in both pathways and terminal regions in cortex from autism donors. Our findings provide morphological evidence to warrant caution when using serotonin enhancing drugs (e.g. SSRIs and receptor agonist) to treat autistic children.This article is part of a Special Issue entitled 'Trends in Neuropharmacology: In Memory of Erminio Costa'. (C) 2011 Elsevier Ltd. All rights reserved.