Entorhinal-CA3 Dual-Input Control of Spike Timing in the Hippocampus by Theta-Gamma Coupling.
Entorhinal-CA3 Dual-Input Control of Spike Timing in the Hippocampus by Theta-Gamma Coupling.
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DOI：
10.1016/j.neuron.2017.02.017
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发表时间：
2017-03-08
期刊：
影响因子：
16.2
通讯作者：
Buzsáki G
中科院分区：
文献类型：
--
作者：
Fernández-Ruiz A;Oliva A;Nagy GA;Maurer AP;Berényi A;Buzsáki G
Theta-Gamma相耦合和theta振荡中的尖峰定时是海马体的显著特征，通常与导航和记忆有关。然而，产生这些关系的机制还没有被很好地理解。采用高空间分辨率电生理学方法，研究了CA3和内嗅觉输入对CA1神经元时序的影响。传入CA3和内嗅觉输入的theta时相偏好和兴奋强度有效地计时了主神经元的活动，并在多个任务和行为状态下调节了不同的CA1中间神经元群体。CA1位置细胞对远端树突抑制的反馈增强减弱了位置野进入时的兴奋性内嗅觉输入，加上近端树突状抑制和周身抑制的反馈抑制，使CA3输入获得了对出口的控制。因此，上游输入与局部机制相互作用，以确定海马神经元的theta相时序，以支持记忆和空间导航。费尔南德斯-鲁伊斯等人。提供证据，证明相位进动现象是更大的尖峰计时机制家族的一部分，并为所有这些机制提供一个共同的解释。CA3和内脏伽马输入的协同作用以及局部抑制决定了发放的时机。
Theta-gamma phase coupling and spike timing within theta oscillations are prominent features of the hippocampus and are often related to navigation and memory. However, the mechanisms that give rise to these relationships are not well understood. Using high spatial resolution electrophysiology, we investigated the influence of CA3 and entorhinal inputs on the timing of CA1 neurons. The theta phase preference and excitatory strength of the afferent CA3 and entorhinal inputs effectively timed the principal neuron activity as well as regulated distinct CA1 interneuron populations in multiple tasks and behavioral states. Feedback potentiation of distal dendritic inhibition by CA1 place cells attenuated the excitatory entorhinal input at place field entry, coupled with feedback depression of proximal dendritic and perisomatic inhibition, allowing the CA3 input to gain control toward the exit. Thus, upstream inputs interact with local mechanisms to determine theta phase timing of hippocampal neurons to support memory and spatial navigation. Fernandez-Ruiz et al. provide evidence that the phase-precession phenomenon is part of a larger family of spike timing mechanisms and provide a common explanation for all of them. Cooperation of CA3 and entorhinal gamma inputs together with local inhibition determine spike timing.