Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients
Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients
复制标题
DOI：
10.1038/jcbfm.2010.140
复制
发表时间：
2010-11-01
影响因子：
6.3
通讯作者：
Laske, Christoph
中科院分区：
文献类型：
--
作者：
Stellos, Konstantinos;Panagiota, Victoria;Laske, Christoph
血管危险因素会导致阿尔茨海默病 (AD) 痴呆的进展并影响血小板活化。然而，迄今为止，尚未研究血小板活化程度作为这一进展的可能潜在机制。在 1 年的随访期间，与认知能力下降缓慢的 AD 患者相比，认知能力快速下降的 AD 患者的血小板活化生物标志物、活化糖蛋白 IIb-IIIa 复合物和 P-选择素的基线表达显着升高。这些结果表明，血小板活化可能是认知能力下降速度的推定预后生物标志物，也是 AD 患者潜在的新治疗目标。脑血流与代谢杂志 (2010) 30, 1817-1820; doi：10.1038/jcbfm.2010.140； 2010 年 8 月 18 日在线发布
Vascular risk factors contribute to the progression of dementia in Alzheimer's disease ( AD) and influence platelet activation. However, the degree of platelet activation as a possible underlying mechanism of this progression has not been studied till now. Significantly higher baseline expression of both platelet activation biomarkers, activated glycoprotein IIb-IIIa complex and P-selectin, was observed in patients with AD with fast cognitive decline compared with AD patients with slow cognitive decline during a 1-year follow-up period. These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1817-1820; doi:10.1038/jcbfm.2010.140; published online 18 August 2010