Laser treatment of congenital facial port-wine stains: Long-term efficacy and complication in chinese patients
Laser treatment of congenital facial port-wine stains: Long-term efficacy and complication in chinese patients
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DOI：
10.1002/lsm.10003
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发表时间：
2002-01-01
影响因子：
2.4
通讯作者：
Chan, PC
中科院分区：
文献类型：
--
作者：
Ho, WS;Chan, HH;Chan, PC
背景和目的：脉冲染料激光（585 nm，450 mu）和可变脉冲宽度频率加倍 Nd:YAG 532 nm 激光已被证明可有效治疗白种人的血管病变，特别是面部葡萄酒色斑。他们在黑皮肤亚洲人中的角色尚未确定。本研究的目的是回顾性评估中国患者激光治疗先天性面部葡萄酒色斑的长期结果和并发症。 研究设计/材料和方法：回顾了 5 年内在主要区域激光中心接受激光治疗的所有葡萄酒色斑患者的档案。这项研究招募了患有先天性面部葡萄酒色斑的中国患者。他们被召回进行问卷评估，评估其清除程度并进行治疗并发症的临床检查。将详细的人口统计数据、问卷调查结果和临床检查结果输入数据库，并在适用的情况下进行统计分析。结果：本研究招募了 107 名先天性面部鲜红斑痣患者。 36 名患者接受了 PDL 治疗，40 名患者接受了 VP532 治疗，31 名患者接受了两种激光系统的治疗。总共进行了 665 次治疗，平均 6.1 +/- 2.8 次（范围 312）。他们的随访时间为 2 至 5 年，平均时间为 3.4 +/- 1.1 年。超过 60% 的患者的清除率超过 25%，大多数患者 (41.1%) 的清除率为 25-50%。不到四分之一的患者 (23%) 的清除率超过 50%，并且没有患者完全清除。接受不同形式激光治疗的患者之间的清除主观评估没有显着差异。治疗后没有患者出现色素沉着复发。百分之十四的患者出现并发症，其中大多数出现色素变化。使用多元回归分析，性别、年龄、治疗次数和使用的激光机类型与较高的并发症发生率无关。结论：中国患者对激光治疗的反应较差，并发症发生率较高。此外，需要更多的治疗次数才能实现最大程度的清除。然而，我们的大多数患者对激光治疗感到满意（患者满意度评分 = 7.25）。如果充分讨论了治疗期望和风险，则不应将深色皮肤患者排除在激光治疗之外。 (C) 2002 Wiley-Liss, Inc.
Background and Objective: Pulsed dye laser (585 nm, 450 mus) and variable pulse width frequency doubled Nd:YAG 532 nm laser have been proven to be effective in treating vascular lesions in Caucasians especially in facial port-wine stain. Their roles in dark-skinned Asian have not been determined. The objective of this study was to assess the long-term outcome and complication of laser treatment of congenital facial port-wine stain in Chinese patients retrospectively.Study Design/Materials and Methods: Files of all patients with port-wine stains who had received laser treatment in a major regional laser center in a 5-year period were reviewed. Chinese patients with congenital facial port-wine stains were recruited for the study. They were called back for questionnaire assessment of their degree of clearance and clinical examination for treatment complication. Detail demographics, result of questionnaire and clinical examination were entered into a database and statistical analyses were conducted where applicable.Results: One hundred and seven patients with congenital facial port-wine stain were recruited for the study. Thirty-six patients had received PDL treatment, 40 patients had VP532 treatment and 31 patients had been treated by both laser systems. A total of 665 treatment sessions had been performed with an average of 6.1 +/- 2.8 sessions (range 312). They had been followed-up from 2 to 5 years with a mean period of 3.4 +/- 1.1 years. Over 60% of patients had more than 25% of clearing and the majority of patients (41.1%) had 25-50% of clearing. Less than one-quarter of patients (23%) experienced a clearing more than 50% and no patient had complete clearing. There was no significant difference in the subjective assessment of clearing between patients that had different forms of laser treatments. No patient had recurrence of pigmentation after treatment. Fourteen percent of patients experienced complications and the majority of them had pigmentary changes. Sex, age, number of treatment session, and type of laser machine used were not related to a higher complication rate using the multiple regression analysis.Conclusions: Chinese patients were less responsive to laser treatment with higher complication rate. In addition, more treatment sessions were required to achieve a maximum clearing. However, most of our patients were satisfied with laser treatment (Patient Satisfaction Score = 7.25). Dark-skinned patients should not be excluded from laser therapy provided that treatment expectations and risks are fully discussed. (C) 2002 Wiley-Liss, Inc.