Increased rates of thrombophilia in women with repeated IVF failures
Increased rates of thrombophilia in women with repeated IVF failures
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DOI：
10.1093/humrep/deh069
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发表时间：
2004-02-01
影响因子：
6.1
通讯作者：
Kupferminc, MJ
中科院分区：
文献类型：
--
作者：
Azem, F;Many, A;Kupferminc, MJ
背景：我们调查了遗传性血栓形成倾向是否在反复 IVF 胚胎移植失败的女性中更为普遍。方法：这项病例对照研究是在一家学术三级护理医院进行的，将 45 名有 4 次或以上 IVF 周期失败史的女性（A 组）与 44 名年龄和种族匹配的表面健康女性（B 组）进行了比较。所有参与者都接受了遗传性血栓形成倾向测试：凝血酶原、V 因子莱顿和亚甲基四氢叶酸还原酶 (MTHFR) 突变，以及蛋白 C、蛋白 S 和抗凝血酶 III 缺陷。结果：排除纯合子 MTHFR，A 组血栓形成倾向的发生率为 26.7%，而 B 组为 9.1%（P = 0.003；比值比 2.9；95% 置信区间 1.02-8.4）。 A组不明原因不孕女性血栓形成倾向的发生率为42.9%（9/21），而B组为18.2%（P < 0.002）。结论：这些数据表明，遗传性血栓形成倾向可能在反复 IVF 失败的病因学中发挥作用，特别是在不明原因生育力的亚组中。
BACKGROUND: We investigated whether hereditary thrombophilia is more prevalent in women with recurrent IVF-embryo transfer failures. METHODS: This case-control study was conducted in an academic tertiary care hospital and compared 45 women with a history of four or more failed IVF cycles (group A) with 44 apparently healthy women matched for age and ethnic origin (group B). All participants were tested for inherited thrombophilias: mutations of prothrombin, factor V Leiden and methylene tetrahydrofolate reductase (MTHFR), and protein C, protein S and antithrombin III deficiencies. RESULTS: Excluding homozygotic MTHFR, the incidence of thrombophilia in group A, was 26.7% compared with 9.1% in group B (P = 0.003; odds ratio 2.9; 95% confidence interval 1.02-8.4). The incidence of thrombophilia in women with unexplained infertility in group A was 42.9% (9/21), compared with 18.2% in group B (P < 0.002). CONCLUSIONS: These data suggest that inherited thrombophilia may play a role in the aetiology of repeated IVF failures, particularly in the subgroup with unexplained fertility.