Genetic and Cellular Contributions to Liver Regeneration
Genetic and Cellular Contributions to Liver Regeneration
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DOI：
10.1101/cshperspect.a040832
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发表时间：
2022-09-01
影响因子：
7.2
通讯作者：
Zhu, Hao
中科院分区：
文献类型：
--
作者：
Liang, Roger;Lin, Yu-Hsuan;Zhu, Hao
肝脏的再生能力代表了理解实体器官中组织修复的范例。在啮齿动物模型中，肝部分切除术后的再生已被很好地理解，而在临床相关慢性损伤的背景下的再生研究较少。由于脂肪肝、肝硬化和肝癌的发病率不断增加，对肝再生的兴趣也在增加。在这里，我们将审查的原则，遗传学和细胞生物学基础肝再生，以及新的方法被用来研究异质性肝组织的维护和修复。
The regenerative capabilities of the liver represent a paradigm for understanding tissue repair in solid organs. Regeneration after partial hepatectomy in rodent models is well understood, while regeneration in the context of clinically relevant chronic injuries is less studied. Given the growing incidence of fatty liver disease, cirrhosis, and liver cancer, interest in liver regeneration is increasing. Here, we will review the principles, genetics, and cell biology underlying liver regeneration, as well as new approaches being used to study heterogeneity in liver tissue maintenance and repair.