Herpes simplex retinitis.
Herpes simplex retinitis.
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单纯疱疹性视网膜炎。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
E. B. Davis
中科院分区：
文献类型：
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作者：
G. W. Cibis;J. Flynn;E. B. Davis
一名健康的18个月大婴儿发生致命性脑炎并伴有视网膜炎。临床表现为白黄色点状病变、血管周围袖状改变和出血。单纯疱疹病毒抗体滴度从入院当天的1：8上升到死亡当天的1：256。死后，在大脑和视网膜中观察到疱疹病毒中发现的典型核内包涵体。通过电子显微镜在脑和视网膜的内核和神经节神经纤维层中发现与疱疹病毒一致的病毒颗粒。这表明疱疹性视网膜炎的直接感染性。推测病毒通过血行传播至视网膜。
Fatal encephalitis with accompanying retinitis developed in a previously healthy 18-month-old infant. Clinically the disease appeared as whitish-yellow punctate lesions, perivascular cuffing, and hemorrhage. The antibody titer to herpes simplex rose from 1:8 on the day of admission to 1:256 on the day of death. Postmortem, intranuclear inclusion bodies that were typical of those found with herpesvirus were seen in the brain and retina. Viral particles consistent with those of herpesvirus were found by electron microscopy in the brain and in the inner-nuclear and ganglion-nerve fiber layers of the retina. This demonstrates the direct infectious nature of herpetic retinitis. Hematogenous spread of the virus to the retina is presumed.