Cognitive processing, discovery of meaning, CD4 decline, and AIDS-related mortality among bereaved HIV-seropositive men
Cognitive processing, discovery of meaning, CD4 decline, and AIDS-related mortality among bereaved HIV-seropositive men
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DOI：
10.1037/0022-006x.66.6.979
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发表时间：
1998-12-01
影响因子：
5.9
通讯作者：
Fahey, JL
中科院分区：
文献类型：
--
作者：
Bower, JE;Kemeny, ME;Fahey, JL
这项研究调查了在应对HN相关压力源时发现意义是否与免疫状态和健康状况的变化有关。40名最近经历过艾滋病相关丧亲的HIV血清阳性男性完成了评估认知过程和发现意义的访谈，并提供了2至3年的随访血样。根据死亡证明确定延长随访期间的艾滋病相关死亡率。正如预测的那样，从事认知处理的男性更有可能从损失中找到意义。此外，发现意义的男性CD4 T细胞水平下降速度较慢，艾滋病相关死亡率较低（所有ps <0.05），与基线健康状况，健康行为和其他潜在的并发症无关。这些结果表明，对压力事件的积极反应，特别是发现意义，可能与积极的免疫和健康结果有关。
This study investigated whether finding meaning in response to an HN-related stressor was associated with changes in immune status and health. Forty HIV-seropositive men who had recently experienced an AIDS-related bereavement completed interviews assessing cognitive processing and finding-meaning after the loss and provided blood samples for a 2- to 3-year follow-up. AIDS-related mortality over an extended follow-up was determined from death certificates. As predicted, men who engaged in cognitive processing were more likely to find meaning from the loss. Furthermore, men who found meaning showed less rapid declines in CD4 T cell levels and lower rates of AIDS-related mortality (all ps < .05), independent of health status at baseline, health behaviors, and other potential con; founds. These results suggest that positive responses to stressful events, specifically the discovery of meaning, may be linked to positive immunologic and health outcomes.