GB virus C hepatitis G virus infection: A favorable prognostic factor in human immunodeficiency virus-infected patients?
GB virus C hepatitis G virus infection: A favorable prognostic factor in human immunodeficiency virus-infected patients?
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DOI：
10.1086/517431
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发表时间：
1998-06-01
影响因子：
6.4
通讯作者：
Manns, MP
中科院分区：
文献类型：
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作者：
Heringlake, S;Ockenga, J;Manns, MP
为探讨GB病毒C （GBV-C）对免疫功能低下患者的影响，对197例人类免疫缺陷病毒（HIV）感染者和120例对照献血者进行了GBV-C RNA和抗e2抗体的检测。197例HIV感染者中有33例（16.8%）检测到GBV-C RNA，而120例献血者中有1例（0.8%）检测到GBV-C RNA (P < 0.001)， 56.8%的HIV患者和9%的献血者先前暴露于GBV-C（抗e2抗体阳性），GBV-C病毒血症与肝炎无关。尽管所有亚组的HIV感染持续时间大致相同，但gbv - c病毒血症患者的CD4细胞计数（344个细胞/ μ L）明显高于暴露患者（259个细胞/ μ L）和未暴露患者（170个细胞/ μ L） （P = 0.017和P < 0.001）。此外，Kaplan-Meier分析显示GBV-C rna阳性的HIV感染患者的累积生存率显著提高，提示GBV-C可能是HIV疾病的一个有利预后因素。
To investigate a possible influence of GB virus C (GBV-C) in immunocompromised patients, the prevalences of GBV-C RNA and anti-E2 antibody in 197 human immunodeficiency virus (HIV)infected patients and in 120 control blood donors were studied. GBV-C RNA was detected in 33 of 197 HIV-infected patients (16.8%) compared with 1 in 120 blood donors (0.8%) (P < .001), Previous exposure to GBV-C (anti-E2 antibody-positive) was shown in 56.8% of HIV patients and in 9% of blood donors, GBV-C viremia was not associated with hepatitis. Despite approximately equal duration of HIV infection in all subgroups, the CD4 cell counts were significantly higher in GBV-C-viremic patients (344 cells/mu L) compared with exposed (259 cells/mu L) and unexposed (170 cells/mu L) patients (P = .017 and P < .001). Furthermore, Kaplan-Meier analysis demonstrated significantly better cumulative survival in GBV-C RNA-positive HIV-infected patients, suggesting that GBV-C might be a favorable prognostic factor in HIV disease.