Bioactive Sesquiterpenoids from the Rhizomes of Acorus calamus
Bioactive Sesquiterpenoids from the Rhizomes of Acorus calamus
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DOI：
10.1021/np300095c
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发表时间：
2012-06-01
影响因子：
5.1
通讯作者：
Yu, De-Quan
中科院分区：
文献类型：
--
作者：
Hao, Zhi-You;Liang, Dong;Yu, De-Quan
从石菖蒲根茎乙醇提取物中分离得到8个新倍半萜(1-8)和1个新倍半萜(9)，命名为菖蒲素A-I。通过比较其实验和计算的 ECD 光谱来确定化合物 8 的绝对构型。其他化合物的绝对构型由它们的圆二色光谱确定。此外，在体外测定中，化合物3、4、7和9（10μM）对APAP诱导的HepG2细胞损伤表现出弱的保肝活性。
Eight new sesquiterpenes (1-8) and one new norsesquiterpene (9) named calamusins A-I were isolated from the ethanol extract of Acorus calamus rhizomes. The absolute configuration of compound 8 was determined by comparing its experimental and calculated ECD spectra. The absolute configurations of the other compounds were determined from their CD spectra. Furthermore, in in vitro assays, compounds 3, 4, 7, and 9 (10 mu M) exhibited weak hepatoprotective activities against APAP-induced HepG2 cell damage.