The role of hypoxia in stem cell differentiation and therapeutics.
The role of hypoxia in stem cell differentiation and therapeutics.
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DOI：
10.1016/j.jss.2009.09.057
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
DiMuzio PJ
中科院分区：
文献类型：
--
作者：
Abdollahi H;Harris LJ;Zhang P;McIlhenny S;Srinivas V;Tulenko T;DiMuzio PJ
干细胞分化成各种细胞系，使其对组织工程和再生医学具有吸引力。特定的微环境线索调节自我更新和分化能力。氧是细胞微环境的重要组成部分，既是代谢底物又是信号分子。氧已被证明对胚胎和成体干细胞有多种影响。本文综述了缺氧在调节干细胞生物学中的作用，特别是关注生长、多能性维持、分化和生长因子的产生。特别注意与治疗性血管生成有关的缺氧和干细胞。我们的结论是，需要进一步的研究，以优化使用缺氧作为刺激各种干细胞功能，包括其在治疗性血管生成的潜在作用。
Stem cells differentiate into a variety of cell lines, making them attractive for tissue engineering and regenerative medicine. Specific micro-environmental cues regulate self-renewal and differentiation capabilities. Oxygen is an important component of the cellular micro-environment, serving as both metabolic substrate and signaling molecule. Oxygen has been shown to have a variety of effects on embryonic and adult stem cells. This review examines the role of hypoxia in regulating stem cell biology, specifically focusing on growth, maintenance of pluripotency, differentiation, and production of growth factors. Particular attention is paid to hypoxia and stem cells in relation to therapeutic angiogenesis. We conclude that further study is needed to optimize the use of hypoxia as a stimulus for various stem cell functions including its potential role in therapeutic angiogenesis.
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影响因子：
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作者：
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通讯作者：
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