Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria
Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria
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DOI：
10.1128/iai.65.10.4090-4093.1997
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发表时间：
1997-10-01
影响因子：
3.1
通讯作者：
Theander, TG
中科院分区：
文献类型：
--
作者：
Hviid, L;Kurtzhals, JAL;Theander, TG
频率和外周血T细胞亚群的绝对数量进行了密切监测急性恶性疟原虫疟疾在22个加纳儿童从一个地区的季节性疟疾传播的高流行。这些儿童患有脑性疟疾或无并发症疟疾（分别为CM或UM）或严重疟疾性贫血。所有患者的外周血T细胞的频率和绝对数量低于正常在疾病的急性期。这种降低在Chi组中最明显，在UM组中最不明显。特别有趣的是，CM患者显示出CD 4（+）细胞的频率显著降低，其数量也比其他临床组恢复得更慢。在所有患者中，T细胞频率在开始治疗后逐渐接近正常值，而绝对数量在恢复到稳态水平之前迅速从低于正常恢复到高于正常。此外，T细胞受体/CD 3复合物的T细胞表面密度最初降低，随后迅速恢复正常，这是所有三个临床组的普遍发现，表明急性疟疾期间外周T细胞低反应性状态。所呈现的数据表明，由于疟疾发作而暂时从外周循环中去除的T细胞的快速治疗诱导的重新出现，并且疾病诱导的T细胞重新分配的程度与疾病的严重程度相关。
Frequencies and absolute numbers of peripheral T-cell subsets were monitored closely following acute Plasmodinm falciparum malaria in 22 Ghanaian children from an area of hyperendemicity for seasonal malaria transmission. The children presented with cerebral or uncomplicated malaria (CM or UM, respectively) or with severe malarial anemia. For all patients the frequencies and absolute numbers of peripheral T cells were lower than normal during the acute stage of disease. This lowering was most pronounced in the Chi group and least pronounced in the UM group. Of particular interest, the CM patients showed markedly reduced frequencies of CD4(+) cells, the number of which also normalized slower than in the other clinical groups. In all patients, the T-cell frequencies gradually approached normal values after the initiation of therapy, whereas the absolute numbers rapidly reverted from lower than normal to higher than normal before returning to steady-state levels. Furthermore, the initially reduced T-cell surface density of the T-cell receptor/CD3 complex, which rapidly normalized, was a general finding for all three clinical groups, suggesting a state of peripheral T-cell hyporesponsiveness during acute malaria. The data presented suggest a rapid therapy-induced reemergence of T cells that had been temporarily removed from the peripheral circulation as a consequence of the malaria attack and that the degree of the disease-induced T-cell reallocation correlates with disease severity.