Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial
Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial
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DOI：
10.1093/ajcn/76.3.549
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发表时间：
2002-09-01
影响因子：
7.1
通讯作者：
Puddey, IB
中科院分区：
文献类型：
--
作者：
Huang, HY;Appel, LJ;Puddey, IB
背景：脂质过氧化可能在动脉粥样硬化的发病机制中起重要作用，特别是在其早期阶段。主要来自体外研究的证据表明，抗氧化维生素可以防止脂质过氧化，维生素C和维生素E具有协同作用。然而，在体内的证据支持这些hypothesissparsive.Objective：其目的是确定维生素C和维生素E，单独或联合使用，对体内脂质peroxidation.Design的影响：我们进行了安慰剂对照，2 × 2析因试验的维生素C（500毫克抗坏血酸/天）和维生素E（400 IU RRR-alpha-生育酚醋酸酯/天）补充184非吸烟者。平均补充时间为2个月。结果指标为尿8-异前列腺素F-2 α、F-尿丙二醛+ 4-羟基烯醛和血清氧自由基吸收能力较基线的变化。(pg/mg肌酸酐）分别为9.0（-125.1，143.1）、-150.0（-275.4，24.6）、-141.3（-230.5，52.1）和-112.5（-234.8，9.8）。这2种维生素对尿8-异前列腺素F-2 α无协同作用。P = 0.12。这两种维生素对尿丙二醛+ 4-羟基烯醛都没有影响。维生素C，而不是维生素E，增加血清氧自由基吸收能力（P = 0.01）。结论：补充维生素C或维生素E单独减少脂质过氧化作用的程度相似。补充维生素C和E的组合没有带来任何好处超过单独的维生素。
Background: Lipid peroxidation may be important in the pathogenesis of atherosclerosis, particularly in its earliest stages. Evidence predominantly from in vitro studies suggests that antioxidant vitamins can prevent lipid peroxidation and that vitamin C and vitamin E have synergistic effects. However, in vivo evidence in support of these hypotheses is sparse.Objective: The objective was to determine the effects of vitamin C and vitamin E, alone or in combination, on in vivo lipid peroxidation.Design: We conducted a placebo-controlled, 2 X 2 factorial trial of vitamin C (500 mg ascorbate/d) and vitamin E (400 IU RRR-alpha-tocopheryl acetate/d) supplementation in 184 nonsmokers. The mean duration of supplementation was 2 mo. The outcome measures were changes from baseline in urinary 8-isoprostaglandin F-2alpha,F- urinary malondialdehyde + 4-hydroxyalkenals, and serum oxygen-radical absorbance capacity.Results: The within-group mean changes (and 95% CIs) in urinary 8-iso-prostaglandin F-2alpha. (pg/mg creatinine) were 9.0 (-125.1, 143.1), -150.0 (-275.4, -24.6), -141.3 (-230.5, -52.1), and -112.5 (-234.8, 9.8) in the placebo, vitamin C alone, vitamin E alone, and vitamins C + E groups, respectively. No synergistic effect of these 2 vitamins on urinary 8-iso-prostaglandin F-2alpha. was observed (P = 0.12). Neither vitamin had an effect on urinary malondialdehyde + 4-hydroxyalkenals. Vitamin C, but not vitamin E, increased serum oxygen-radical absorbance capacity (P = 0.01).Conclusions: Supplementation with vitamin C or vitamin E alone reduced lipid peroxidation to a similar extent. Supplementation with a combination of vitamins C and E conferred no benefit beyond that of either vitamin alone.