DNA dynamics in a microchannel
DNA dynamics in a microchannel
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DOI：
10.1103/physrevlett.91.038102
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发表时间：
2003-07-18
影响因子：
8.6
通讯作者：
de Pablo, JJ
中科院分区：
文献类型：
--
作者：
Jendrejack, RM;Dimalanta, ET;de Pablo, JJ
采用扩展的布朗动力学模拟方法研究了长链DNA分子在微通道中的动力学行为。的弛豫时间增加，由于限制与缩放预测。在流动过程中，分子向通道中心线迁移，从而根据分子量分离。捕获这些影响需要详细纳入溶剂流的模拟方法，证明了流体动力学效应的重要性，在动力学的限制大分子。
An extended Brownian dynamics simulation method is used to characterize the dynamics of long DNA molecules flowing in microchannels. The relaxation time increases due to confinement in agreement with scaling predictions. During flow the molecules migrate toward the channel center line, and thereby segregate according to molecular weight. Capturing these effects requires the detailed incorporation of solvent flow in the simulation method, demonstrating the importance of hydrodynamic effects in the dynamics of confined macromolecules.