Ethnic differences in knowledge and attitudes about BRCA1 testing in women at increased risk
Ethnic differences in knowledge and attitudes about BRCA1 testing in women at increased risk
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DOI：
10.1016/s0738-3991(97)00064-5
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发表时间：
1997-09-01
影响因子：
3.5
通讯作者：
Lerman, C
中科院分区：
文献类型：
--
作者：
Hughes, C;GomezCaminero, A;Lerman, C
BRCA1突变检测的知情同意需要充分了解癌症的遗传模式以及DNA检测的好处、局限性和风险。这项研究调查了有关乳腺癌遗传的知识，以及对高危女性进行乳腺癌-卵巢癌易感性基因检测的态度。对407名18-75岁的非裔美国人和高加索女性的知识和态度进行了测量，她们至少有一个一级亲属(FDR)患有乳腺癌和/或卵巢癌。平均知识得分为6.0分(总分为11分，标准差=2.15)。与高加索女性相比，非裔美国女性的知识水平较低，对基因检测的好处持更积极的态度。在对测试的局限性和风险的态度上没有明显的种族差异，然而，收入与这一结果呈负相关。关于乳腺癌-卵巢癌风险的基因检测的知识和态度的种族差异可能归因于接触遗传信息和卫生保健提供者转介的不同。(C)1997年爱思唯尔爱尔兰科学有限公司。
Informed consent for BRCA1 mutation testing will require adequate knowledge of patterns of inheritance of cancer and the benefits, limitations, and risks of DNA testing. This study examined knowledge about the inheritance of breast cancer and attitudes about genetic testing for breast-ovarian cancer susceptibility in women at increased risk. Knowledge and attitudes were measured in 407 African American and Caucasian women aged 18-75 who had at least one first-degree relative (FDR) with breast and/or ovarian cancer. The average knowledge score was 6.0 out of a total of 11 (S.D. = 2.15). Compared to Caucasian women, African American women had lower levels of knowledge and had more positive attitudes about the benefits of genetic testing. There were no significant ethnic differences in attitudes about the limitations and risks of testing, however, income was negatively associated with this outcome. Ethnic differences in knowledge and attitudes about genetic testing for breast-ovarian cancer risk may be attributable to differences in exposure to genetic information and referral by health care providers. (C) 1997 Elsevier Science Ireland Ltd.