Three-dimensional diffusion tensor magnetic resonance microimaging of adult mouse brain and hippocampus
Three-dimensional diffusion tensor magnetic resonance microimaging of adult mouse brain and hippocampus
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DOI：
10.1006/nimg.2001.1012
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发表时间：
2002-04-01
期刊：
影响因子：
5.7
通讯作者：
Mori, S
中科院分区：
文献类型：
--
作者：
Zhang, JY;van Zijl, PCM;Mori, S
在离体小鼠大脑和离体海马体中研究了使用扩散张量信息作为 MR 显微成像的附加对比。弥散张量成像 (DTI) 提供了独特的对比度，可识别灰质的许多内部结构，例如海马体、丘脑和皮质。在海马体中，可以使用各向同性水扩散常数来识别颗粒层和锥体层。分子层和辐射层是根据颜色编码 DTI 显示的特征纤维结构来识别的。这些结构的识别允许重建它们的 3D 体积。因此，高分辨率 DTI 具有作为小鼠大脑 3D 表征工具的巨大潜力。 (C) 2002 年爱思唯尔科学（美国）。
The use of diffusion tensor information as an additional contrast in MR microimaging was investigated in ex vivo mouse brain and isolated hippocampus. Diffusion Tensor Imaging (DTI) provided unique contrast to identify many internal structures of the gray matter such as hippocampus, thalamus, and cortex. In hippocampus, stratum granulosum and stratum pyramidale could be identified using the isotropic water diffusion constant. Stratum moleculare and stratum radiatum were identified from their characteristic fiber architecture revealed by color-coded DTI. Identification of these structures allowed reconstruction of their 3-D volume. Thus, high-resolution DTI has excellent potential as a tool for 3-D characterization of murine brains. (C) 2002 Elsevier Science (USA).