Correlation analysis of collagen proportionate area in Budd-Chiari syndrome: A preliminary clinicopathological study.
Correlation analysis of collagen proportionate area in Budd-Chiari syndrome: A preliminary clinicopathological study.
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布加综合征胶原比例面积的相关分析：初步临床病理学研究。
DOI：
10.12998/wjcc.v7.i2.130
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Xing-Shun Qi
中科院分区：
文献类型：
--
作者：
Fu-Liang He;Chuan Li;Fu-Quan Liu;Xing-Shun Qi
背景:。胶原比例面积（CPA）是评价肝纤维化严重程度的重要指标。布-恰里综合征常发展为肝纤维化和肝硬化。CPA可能在Budd-Chiari综合征的病理进展中起重要作用。目的：探讨CPA在预测Budd-Chiari综合征患者预后中的作用。9例Budd-Chiari综合征患者接受经颈静脉肝内门体分流术（TIPS）。测定中值CPA水平及与TIPS预后的相关性。中位CPA为23.07%（范围：0%-40.20%）。Pearson's χ2检验显示，CPA与胃肠道出血史（Pearson's系数：0.832,P = 0.005）、丙氨酸转氨酶（Pearson's系数：-0.694,P = 0.038）、凝血酶原时间（Pearson's系数：0.68,P = 0.044）有显著相关性。尽管TIPS后CPA与分流功能障碍或肝性脑病无显著相关性，但TIPS后发生分流功能障碍或肝性脑病的患者CPA绝对值相对较大。这项初步的临床病理研究发现，CPA对TIPS治疗Budd-Chiari综合征患者的预后有边际影响。
BACKGROUND:.Collagen proportionate area (CPA) is an important index for assessing the severity of liver fibrosis. Budd-Chiari syndrome can frequently progress to liver fibrosis and cirrhosis. CPA might play an important role in the pathological progress of Budd-Chiari syndrome...AIM:.To explore the role of CPA in predicting the outcomes of patients with Budd-Chiari syndrome...METHODS:.Nine patients with Budd-Chiari syndrome undergoing transjugular intrahepatic portosystemic shunt (TIPS) were included. The median CPA level and correlation of CPA and prognosis of TIPS were determined...RESULTS:.Median CPA was 23.07% (range: 0%-40.20%). Pearson's χ2 test demonstrated a significant correlation of CPA with history of gastrointestinal bleeding (Pearson's coefficient: 0.832, P = 0.005), alanine aminotransferase (Pearson's coefficient: -0.694, P = 0.038), and prothrombin time (Pearson's coefficient: 0.68, P = 0.044). Although CPA was not significantly correlated with shunt dysfunction or hepatic encephalopathy after TIPS, the absolute CPA was relatively larger in patients who developed shunt dysfunction or hepatic encephalopathy after TIPS...CONCLUSION:.This preliminary clinicopathological study found a marginal effect of CPA on the outcomes of Budd-Chiari syndrome patients treated with TIPS.