Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma
Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma
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口腔鳞癌内皮CXCR7表达与临床病理因素的相关性
DOI：
10.1111/pin.13094
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发表时间：
2021
影响因子：
2.2
通讯作者：
Hida Kyoko
中科院分区：
文献类型：
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作者：
Yanagiya Misa;Dawood Randa I. H.;Maishi Nako;Hida Yasuhiro;Torii Chisaho;Annan Dorcas A.;Kikuchi Hiroshi;Yanagawa Matsuda Aya;Kitamura Tetsuya;Ohiro Yoichi;Shindoh Masanobu;Tanaka Shinya;Kitagawa Yoshimasa;Hida Kyoko
口腔鳞状细胞癌（OSCC）损害功能和感官，导致生活质量差。生物标志物可以预测疾病轨迹并导致有效的治疗。转录组学已经鉴定出与正常内皮细胞（NEC）相比在肿瘤内皮细胞（TEC）中上调的基因。其中，趋化因子受体7（CXCR 7）在多种肿瘤的TEC中高度表达，并参与TEC的血管生成。然而，OSCC血管中CXCR 7的水平尚未得到充分研究。本研究旨在探讨CXCR 7在口腔鳞癌中的表达及其与临床病理因素的关系。对1996年至2008年在北海道大学医院切除的59例OSCC组织标本进行CXCR 7和CD 34的免疫组化。通过CXCR 7 +/CD 34+血管的比率评价血管中CXCR 7的表达。CXCR 7在肿瘤和非肿瘤部分中的表达分别为42%和19%，表明CXCR 7在TEC中的表达高于NEC。TEC中的CXCR 7表达与晚期T分期和癌症分期相关。低表达CXCR 7患者的总生存率和无病生存率高于高表达CXCR 7患者。这些结果表明，CXCR 7在血管中的表达可能是一个有用的诊断和预后指标的口腔鳞癌患者。
Oral squamous cell carcinoma (OSCC) impairs functionality and sensuousness resulting in poor quality of life. Biomarkers can predict disease trajectory and lead to effective treatments. Transcriptomics have identified genes that are upregulated in tumor endothelial cells (TECs) compared with normal endothelial cells (NECs). Among them, chemokine receptor 7 (CXCR7) is highly expressed in TECs of several cancers and involved in angiogenesis of TECs. However, levels of CXCR7 in OSCC blood vessels have not been fully investigated. In this study, we analyzed the correlation between CXCR7 expression in TECs and clinicopathological factors in OSCC. Immunohistochemistry for CXCR7 and CD34 was performed on 59 OSCC tissue specimens resected between 1996 and 2008 at Hokkaido University Hospital. CXCR7 expression in blood vessels was evaluated by the ratio of CXCR7+/CD34+ blood vessels. CXCR7 expression was 42% and 19% in tumor and non‐tumor parts, respectively, suggesting that CXCR7 expression is higher in TECs than in NECs. CXCR7 expression in TECs correlated with advanced T‐stage and cancer stage. Overall survival and disease‐free survival rates were higher in low‐expressing CXCR7 patients than in high‐expressing. These results suggest that CXCR7 expression in blood vessels may be a useful diagnostic and prognostic marker for OSCC patients.