Peptide Vaccine: Progress and Challenges.
Peptide Vaccine: Progress and Challenges.
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DOI：
10.3390/vaccines2030515
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发表时间：
2014-07-02
期刊：
影响因子：
7.8
通讯作者：
Murthy AK
中科院分区：
文献类型：
--
作者：
Li W;Joshi MD;Singhania S;Ramsey KH;Murthy AK
几十年来，传统的疫苗策略在降低传染病的死亡率和发病率方面非常有效。常规疫苗（例如包括整个生物体或大蛋白质的那些疫苗）的祸根似乎是包括不必要的抗原负荷，其不仅对保护性免疫应答贡献很小，而且通过诱导变应原性和/或反应原性应答使情况复杂化。肽疫苗是一种有吸引力的替代策略，其依赖于使用短肽片段来工程化诱导高度靶向的免疫应答，从而避免变应原性和/或反应原性序列。相反，用于分离的肽疫苗通常是弱免疫原性的，并且需要颗粒载体用于递送和佐剂化。本文就肽疫苗在靶向诱导免疫应答方面的优势和注意事项以及针对各种疾病的肽疫苗的研究进展作一综述。此外，我们还讨论了颗粒载体策略的发展以及将此类技术与肽疫苗结合时安全性方面的固有挑战。
Conventional vaccine strategies have been highly efficacious for several decades in reducing mortality and morbidity due to infectious diseases. The bane of conventional vaccines, such as those that include whole organisms or large proteins, appear to be the inclusion of unnecessary antigenic load that, not only contributes little to the protective immune response, but complicates the situation by inducing allergenic and/or reactogenic responses. Peptide vaccines are an attractive alternative strategy that relies on usage of short peptide fragments to engineer the induction of highly targeted immune responses, consequently avoiding allergenic and/or reactogenic sequences. Conversely, peptide vaccines used in isolation are often weakly immunogenic and require particulate carriers for delivery and adjuvanting. In this article, we discuss the specific advantages and considerations in targeted induction of immune responses by peptide vaccines and progresses in the development of such vaccines against various diseases. Additionally, we also discuss the development of particulate carrier strategies and the inherent challenges with regard to safety when combining such technologies with peptide vaccines.