Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L x GSK3β mice by delaying brainstem tauopathy
Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L x GSK3β mice by delaying brainstem tauopathy
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DOI：
10.1016/j.nbd.2014.03.016
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发表时间：
2014-07-01
影响因子：
6.1
通讯作者：
Van Leuven, Fred
中科院分区：
文献类型：
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作者：
Crespo-Biel, Natalia;Theunis, Clara;Van Leuven, Fred
Tau.P301L转基因小鼠在8至11个月龄之间遭受过早死亡，这是由控制呼吸的自主脑干回路中的tau病变引起的上气道缺陷引起的（Dutschmann等人，2010年）。在个体小鼠中，临床表型从抱臂、一般运动障碍到体重严重减轻逐渐迅速（3-6周）演变为宣告即将死亡的终末期（
Tau.P301L transgenic mice suffer precocious mortality between ages 8 and 11 months, resulting from upper airway defects caused by tauopathy in autonomic brainstem circuits that control breathing (Dutschmann et al., 2010). In individual mice, the clinical phenotype evolves progressively and rapidly (3-6 weeks) from clasping, over general motor impairment to severe reduction in body-weight into the terminal phase that announces imminent death (