EXPRESSION OF MRP14, 27E10, INTERFERON-ALPHA AND LEUKOCYTE COMMON ANTIGEN BY REACTIVE MICROGLIA IN POSTMORTEM HUMAN BRAIN-TISSUE
EXPRESSION OF MRP14, 27E10, INTERFERON-ALPHA AND LEUKOCYTE COMMON ANTIGEN BY REACTIVE MICROGLIA IN POSTMORTEM HUMAN BRAIN-TISSUE
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DOI：
10.1016/0165-5728(94)90046-9
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发表时间：
1994-03-01
影响因子：
3.3
通讯作者：
MCGEER, PL
中科院分区：
文献类型：
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作者：
AKIYAMA, H;IKEDA, K;MCGEER, PL
我们用化学方法研究了一组白细胞相关分子在对照组和阿尔茨海默病（AD）患者死后人脑组织中的定位。小胶质细胞组成型表达具有CD 45 RB决定簇的白细胞共同抗原（LCA）。根据激活状态，小胶质细胞对髓样细胞特异性钙结合蛋白MRP 14、具有CD 45 RO决定簇的LCA、干扰素-α和单克隆抗体27 E10识别的抗原呈阳性。在AD病变中，这些细胞以与慢性炎症状态一致的方式被激活。本研究的结果进一步显示了激活的小胶质细胞和髓系激活的白细胞之间的蛋白质表达的相似性。
We have immunohistochemically investigated the localization of a panel of leukocyte-related molecules in postmortem human brain tissue from control subjects and patients with Alzheimer's disease (AD). Microglia constitutively express leukocyte common antigens (LCA) with CD45RB determinants. Depending on the state of activation, microglia become positive for the myeloid cell-specific calcium binding protein MRP14, LCA with CD45RO determinant, interferon-alpha, and an antigen recognized by monoclonal antibody 27E10. In AD lesions, these cells are activated in a manner consistent with a chronic inflammatory state. The results of this study have shown further parallels in protein expression between activated microglia and activated leukocytes of the myeloid lineage.