Preparation of fluorescent organometallic porphyrin complex nanogels of controlled molecular structure via reverse-emulsion click chemistry.
Preparation of fluorescent organometallic porphyrin complex nanogels of controlled molecular structure via reverse-emulsion click chemistry.
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DOI：
10.1002/marc.201200337
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发表时间：
2012-09
影响因子：
4.6
通讯作者：
G. Fu;Hua Jiang;F. Yao;Li‐Qun Xu;Jun Ling;E. Kang
中科院分区：
文献类型：
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作者：
G. Fu;Hua Jiang;F. Yao;Li‐Qun Xu;Jun Ling;E. Kang
在这里，我们是第一个报道一种新的方法来制备定义明确的聚（乙二醇）（PEG）荧光纳米凝胶，具有明确的分子结构和所需的功能，通过反相（细）乳液铜（I）催化的叠氮化物-炔环加成（REM-CuAAC）。成功制备了含羟基和镓卟啉复合物的纳米凝胶（镓卟啉-OH纳米凝胶）以及含叶酸功能基的镓卟啉复合物的纳米凝胶（镓卟啉-FA纳米凝胶）。获得直径为30和120 nm的纳米凝胶，并且它们在700-800 nm的波长范围内表现出发射最大值。纳米凝胶可以在近红外（NIR）成像中找到用途，这归因于它们的荧光和它们对细胞亲和力的功能。
Here, we are the first to report a novel approach to preparing well-defined poly(ethylene glycol) (PEG) fluorescent nanogels, with well-defined molecular structures and desired functionalities via reverse (mini)emulsion copper(I)-catalyzed azide-alkyne cycloaddition (REM-CuAAC). Nanogels with hydroxyl groups and Ga-porphyrin complex (Ga-porphyrin-OH nanogels), as well as with Ga-porphyrin complex and folate functional groups (Ga-porphyrin-FA), are successfully prepared. Nanogels of 30 and 120 nm in diameter are obtained and they exhibit an emission maxima within the wavelength range 700-800 nm. The nanogels could find uses in near infrared (NIR) imaging attributable to their fluorescence and their functionality for cell affinity.