ELECTROCHEMOTHERAPY POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY LOCAL ELECTRIC PULSES
ELECTROCHEMOTHERAPY POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY LOCAL ELECTRIC PULSES
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DOI：
10.1016/0277-5379(91)90064-k
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发表时间：
1991-01-01
影响因子：
8.4
通讯作者：
PAOLETTI, C
中科院分区：
文献类型：
--
作者：
MIR, LM;ORLOWSKI, S;PAOLETTI, C
在细胞培养中，一些抗癌药物，特别是博来霉素的细胞毒性可以通过将细胞暴露于无细胞毒性的电脉冲而大大增强。携带皮下移植肿瘤的裸小鼠或传统小鼠接受肌内注射博来霉素，然后局部输送与体外使用的类似的电脉冲。肿瘤缩小，甚至根除后，这种电化学治疗。因此，局部电脉冲可显著增强博莱霉素在小鼠中的抗肿瘤作用。
In cell culture the cytotoxicity of some anticancer drugs, especially bleomycin, can be greatly enhanced by exposing cells to non-cytotoxic electric pulses. Nude or conventional mice bearing subcutaneous transplanted tumours were treated with intramuscular doses of bleomycin followed by local delivery of electric pulses similar to those used in vitro. Tumours were reduced and even eradicated after this electrochemotherapy. Thus the antitumour effects of bleomycin in mice can be considerably potentiated by local electric pulses.