Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway.
Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway.
复制标题
在挪威阿克斯胡斯县，婴儿期急性细支气管炎是喘息的危险因素，导致肺功能下降七年。
DOI：
10.1186/1471-2431-5-31
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发表时间：
2005-08-18
期刊：
影响因子：
2.4
通讯作者：
Nakstad, Britt
中科院分区：
文献类型：
--
作者：
Fjaerli, Hans-Olav;Farstad, Teresa;Rod, Gisle;Ufert, Gunn Kristin;Gulbrandsen, Pal;Nakstad, Britt
急性病毒性细支气管炎是我们地区婴儿期住院的最常见原因之一，呼吸道合胞病毒（RSV）历来是主要病原体。许多患有早期RSV细支气管炎的婴儿在住院后多年持续支气管高反应性，其原因可能是多因素的。本研究的主要目的是调查我们地区婴儿期因任何急性病毒性细支气管炎而住院的儿童（不仅是因RSV所致）与婴儿期未因急性细支气管炎住院的儿童相比，是否在7岁之前有更多的随后喘息发作，并且在该年龄时肺功能降低。次要目的是根据相同的终点，比较确诊为RSV细支气管炎（RS+）的住院婴儿与非RSV细支气管炎（RS-）的住院婴儿。1993-1994年连续两个冬季至少有一次急性病毒性细支气管炎住院的57名婴儿在7岁时进行了检查。年龄匹配的对照组64名儿童，谁没有在婴儿期急性病毒性细支气管炎住院，从当地小学招募。流行病学和临床数据从出院记录中回顾性收集，并通过随访时的结构化临床访谈和体格检查收集。婴儿期因细支气管炎住院的儿童与年龄匹配的对照组相比，肺功能下降，更经常发生喘息发作，目前的药物治疗和7岁时的哮喘随访。他们也有较低的平均出生体重和更多的一阶家庭成员患有哮喘。我们没有发现RSV+和RSV-组之间的显著差异。与年龄匹配的未因早期毛细支气管炎住院的儿童相比，因早期毛细支气管炎住院的儿童易发生反复喘息和肺功能降低7年。我们认为，长期支气管高反应性可能遵循早期生活RSV阴性以及RSV阳性毛细支气管炎。
Acute viral bronchiolitis is one of the most common causes of hospitalisation during infancy in our region with respiratory syncytial virus (RSV) historically being the major causative agent. Many infants with early-life RSV bronchiolitis have sustained bronchial hyperreactivity for many years after hospitalisation and the reasons for this are probably multifactorial. The principal aim of the present study was to investigate if children hospitalised for any acute viral bronchiolitis during infancy in our region, and not only those due to RSV, had more episodes of subsequent wheezing up to age seven years and reduced lung function at that age compared to children not hospitalised for acute bronchiolitis during infancy. A secondary aim was to compare the hospitalised infants with proven RSV bronchiolitis (RS+) to the hospitalised infants with non-RSV bronchiolitis (RS-) according to the same endpoints. 57 infants hospitalised at least once with acute viral bronchiolitis during two consecutive winter seasons in 1993–1994 were examined at age seven years. An age-matched control group of 64 children, who had not been hospitalised for acute viral bronchiolitis during infancy, were recruited from a local primary school. Epidemiological and clinical data were collected retrospectively from hospital discharge records and through structured clinical interviews and physical examinations at the follow-up visit. The children hospitalised for bronchiolitis during infancy had decreased lung function, more often wheezing episodes, current medication and follow-up for asthma at age seven years than did the age matched controls. They also had lower average birth weight and more often first order family members with asthma. We did not find significant differences between the RSV+ and RSV- groups. Children hospitalised for early-life bronchiolitis are susceptible to recurrent wheezing and reduced pulmonary function by seven years compared to age-matched children not hospitalised for early-life bronchiolitis. We propose that prolonged bronchial hyperreactivity could follow early-life RSV negative as well as RSV positive bronchiolitis.