Cognitive and neural consequences of memory suppression in major depressive disorder.
Cognitive and neural consequences of memory suppression in major depressive disorder.
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重度抑郁症中记忆抑制的认知和神经后果。
DOI：
10.3758/s13415-016-0464-x
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发表时间：
2017-02
期刊：
影响因子：
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通讯作者：
Gotlib IH
中科院分区：
文献类型：
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作者：
Sacchet MD;Levy BJ;Hamilton JP;Maksimovskiy A;Hertel PT;Joormann J;Anderson MC;Wagner AD;Gotlib IH
在严重抑郁障碍(MDD)中，认知中的负面偏见被一致地记录下来，包括控制负面材料处理的能力困难。虽然负性信息加工偏差已经被用行为和神经成像范式进行了研究，但对抑郁症患者抑制从长期记忆中提取负性信息的困难进行的研究相对较少。在这项研究中，我们使用思考/不思考范式和功能磁共振成像来评估被诊断为抑郁症的个体和健康对照组记忆抑制的认知和神经后果。参与者表现出典型的行为遗忘效应，但与我们的假设相反，抑郁和非抑郁参与者之间，中性记忆和负面记忆之间没有差异。与对照组相比，抑郁个体在记忆抑制时，右额中回表现出更大的活动，而不考虑抑制刺激的价态，而在涉及负价刺激的记忆抑制时，杏仁核和海马区表现出不同的活动。这些发现表明，抑郁个体在抑制长期记忆的过程中表现出神经异常的特征，这增加了我们对MDD负面认知偏差的大脑基础的理解。本文的在线版本(doi：10.3758/s13415-0160464-x)包含补充材料，授权用户可以使用。
Negative biases in cognition have been documented consistently in major depressive disorder (MDD), including difficulties in the ability to control the processing of negative material. Although negative information-processing biases have been studied using both behavioral and neuroimaging paradigms, relatively little research has been conducted examining the difficulties of depressed persons with inhibiting the retrieval of negative information from long-term memory. In this study, we used the think/no-think paradigm and functional magnetic resonance imaging to assess the cognitive and neural consequences of memory suppression in individuals diagnosed with depression and in healthy controls. The participants showed typical behavioral forgetting effects, but contrary to our hypotheses, there were no differences between the depressed and nondepressed participants or between neutral and negative memories. Relative to controls, depressed individuals exhibited greater activity in right middle frontal gyrus during memory suppression, regardless of the valence of the suppressed stimuli, and differential activity in the amygdala and hippocampus during memory suppression involving negatively valenced stimuli. These findings indicate that depressed individuals are characterized by neural anomalies during the suppression of long-term memories, increasing our understanding of the brain bases of negative cognitive biases in MDD. The online version of this article (doi:10.3758/s13415-016-0464-x) contains supplementary material, which is available to authorized users.