A Novel Cytokine Pathway Suppresses Glial Cell Melanogenesis after Injury to Adult Nerve
A Novel Cytokine Pathway Suppresses Glial Cell Melanogenesis after Injury to Adult Nerve
复制标题
一种新的细胞因子途径抑制成体神经损伤后胶质细胞黑色素生成
DOI：
10.1523/jneurosci.22-22-09831.2002
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
N. Ratner
中科院分区：
文献类型：
--
作者：
T. Rizvi;Yuan;A. Sidani;R. Atit;D. Largaespada;R. Boissy;N. Ratner
神经脊产生多种类型的细胞，包括雪旺细胞、神经元和黑素细胞。成年神经脊来源的细胞在多大程度上保持可塑性，此前还没有进行过测试。我们报道，切断成年小鼠坐骨神经可以诱导神经束周围、肌束之间和皮下组织中的色素沉积。色素细胞来自成年神经，因为即使将神经片段移植到酪氨酸酶缺失的白化小鼠体内，也会发生色素沉着。色素缺陷在1型神经纤维瘤病(NF1)患者中普遍存在。Nf1基因突变的小鼠在神经损伤后表现出更强的色素沉着，偶尔会形成色素沉着和无色素肿瘤。Nf1神经和Nf1宿主环境都有助于增强色素沉着。移植纯化的Nf1突变型胶质细胞[S100+-p75NGFR+-GFAP+-EGFR+或S100+-p75NGFR+-GFAP+-EGFR−]模拟神经源性色素沉着。NF1蛋白，神经纤维素，是一个RAS-GAP，作用于一些已定义的受体酪氨酸激酶的下游，包括[β-Common(βc)]，粒细胞和单核细胞集落刺激因子的共同共同受体，白细胞介素3(IL3)和IL5。环境中的细胞因子有潜在的抑制色素沉着的潜力，正如空白小鼠的神经损伤实验所表明的那样；当βc缺失或Nf1突变时，黑素合成增加。因此，成年神经胶质细胞表型在神经损伤后通过神经纤维蛋白对细胞因子的反应得以维持。
The neural crest gives rise to numerous cell types, including Schwann cells, neurons, and melanocytes. The extent to which adult neural crest-derived cells retain plasticity has not been tested previously. We report that cutting adult mouse sciatic nerve induces pigmentation around nerve fascicles, among muscle bundles, and in the hypodermis. Pigmented cells are derived from adult nerve, because pigmentation occurs even when nerve fragments are grafted into tyrosinase null albino mice. Pigmentation defects are pervasive in patients with neurofibromatosis type 1 (NF1). Mice hemizygous for Nf1 mutations show enhanced pigmentation after nerve lesion and occasionally form pigmented and unpigmented tumors. TheNf1 nerve and the Nf1 host environment both contribute to enhanced pigmentation. Grafted purifiedNf1 mutant glial cells [S100+–p75NGFR+–GFAP+–EGFR+or S100+–p75NGFR+–GFAP+–EGFR−] mimic nerve-derived pigmentation. The NF1 protein, neurofibromin, is a Ras-GAP that acts downstream of a few defined receptor tyrosine kinases, including [β-common (βc)] the shared common receptor for granulocyte and monocyte colony-stimulating factor, interleukin-3 (IL3), and IL5. Cytokines in the environment have the potential to suppress pigmentation as shown by nerve injury experiments in null mice; when is βc absent orNf1 is mutant, melanogenesis is increased. Thus, the adult nerve glial cell phenotype is maintained after nerve injury by response to cytokines, through neurofibromin.
登录
查看更多内容
影响因子：
16
作者：
Birnbaum, RA;O'Marcaigh, A;Shannon, KM
通讯作者：
Shannon, KM
影响因子：
8
作者：
Haesun A Kim;T. Rosenbaum;Marchionni Ma;N. Ratner;D. Je
通讯作者：
Haesun A Kim;T. Rosenbaum;Marchionni Ma;N. Ratner;D. Je
对 Nf1 突变体中黑素细胞前体的分析表明，MGF/KIT 信号传导促进定向细胞迁移，与其在细胞存活中的功能无关。
DOI：
10.1006/dbio.2001.0167
发表时间：
2001
期刊：
Developmental biology.
影响因子：
--
作者：
Wehrle-Haller,B;Meller,M;Weston,JA
通讯作者：
Weston,JA
影响因子：
15.9
作者：
DeClue, JE;Heffelfinger, S;Ratner, N
通讯作者：
Ratner, N
影响因子：
56.9
作者：
Vogel, KS;Klesse, LJ;Parada, LF
通讯作者：
Parada, LF