Association of lipoprotein-associated phospholipase A2 mass with asymptomatic cerebral artery stenosis.
Association of lipoprotein-associated phospholipase A2 mass with asymptomatic cerebral artery stenosis.
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脂蛋白相关磷脂酶 A2 质量与无症状脑动脉狭窄的关系
DOI：
10.1111/jcmm.13521
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发表时间：
2018-04
影响因子：
5.3
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Wang Y;Zhou B;Zhou P;Yao Y;Cui Q;Liu Y;Yang J;Wu S;Zhao X;Zhou Y
脑动脉狭窄是缺血性脑卒中最重要的病因。脂蛋白相关磷脂酶A2 （Lp - PLA2）在动脉粥样硬化中起着两种不同的作用（促炎和抗炎），Lp - PLA2质量与心脑血管事件之间的关系在以往的研究中并不一致。2010 - 2011年进行了一项横断面研究，包括2012名年龄≥40岁的华北成年人，以调查Lp - PLA2肿块是否与无症状脑动脉狭窄（ACAS）相关。采用酶联免疫吸附试验（ELISA）测定血清Lp - PLA2质量。所有参与者都接受了经颅多普勒（TCD）和双侧颈动脉双工超声来评估颅内动脉狭窄（ICAS）和颅外动脉狭窄（ECAS）。参与者的血清Lp‐PLA2质量中位数为140.74 ng/mL（四分位数范围：131.79‐158.07 ng/mL）。在控制血管危险因素后，将Lp‐PLA2的第4四分位数与第1四分位数进行比较时，校正优势比（OR）分别为1.98（95%可信区间（CI）： 1.42‐2.78）、1.79 （95% CI: 1.08‐2.94）和1.87 （95% CI: 1.28‐2.73）。这些独立的显著关联在男性或老年亚组中仍然具有统计学意义，但在女性或中年参与者中则没有。在华北地区，Lp‐PLA2质量与由ACAS、ICAS和ECAS测定的亚临床动脉粥样硬化呈正相关，特别是在男性和老年参与者中，这表明血清Lp‐PLA2质量可能是检测成人ACAS的潜在生物标志物。
Cerebral artery stenosis (CAS) is the most important causes of ischaemic stroke. Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) plays 2 diverse roles in atherosclerosis (pro‐inflammatory and anti‐inflammatory), and the association between Lp‐PLA2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross‐sectional study including 2012 North Chinese adults aged ≥40 years was performed in 2010‐2011 to investigate whether Lp‐PLA2 mass is associated with asymptomatic cerebral artery stenosis (ACAS). Serum Lp‐PLA2 mass was determined by enzyme‐linked immunosorbent assay (ELISA). All participants underwent transcranial Doppler (TCD) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (ICAS) and extracranial arterial stenosis (ECAS). The median serum Lp‐PLA2 mass of the participants was 140.74 ng/mL (interquartile range: 131.79‐158.07 ng/mL). The adjusted odds ratio (OR) when comparing the 4th quartile to the 1st quartile of Lp‐PLA2 was 1.98 (95% confidence interval (CI): 1.42‐2.78), 1.79 (95% CI: 1.08‐2.94) and 1.87 (95% CI: 1.28‐2.73) for the occurrence of ACAS, asymptomatic ECAS and asymptomatic ICAS, respectively, after controlling for vascular risk factors. These independently significant associations remained statistically significant in the male or elderly subgroups, but not in females or middle‐aged participants. Lp‐PLA2 mass is positively correlated with subclinical atherosclerosis determined by ACAS, ICAS and ECAS in North Chinese, particularly in male and older participants, suggesting that serum Lp‐PLA2 mass might be potential biomarker for the detection of ACAS in the adults.
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