Predicting the degradation behavior of magnesium alloys with a diffusion-based theoretical model and in vitro corrosion testing
Predicting the degradation behavior of magnesium alloys with a diffusion-based theoretical model and in vitro corrosion testing
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利用基于扩散的理论模型和体外腐蚀测试预测镁合金的降解行为
DOI：
10.1016/j.jmst.2019.02.004
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发表时间：
2019
影响因子：
10.9
通讯作者：
Yufeng Zheng
中科院分区：
文献类型：
--
作者：
Zhenquan Shen;Ming Zhao;Dong Bian;Danni Shen;Xiaochen Zhou;Jianing Liu;Yang Liu;Hui Guo;Yufeng Zheng
由于具有良好的生物降解性，镁合金在医疗器械领域显示出巨大的应用潜力。然而，定量表征镁合金的降解行为仍然是一个挑战。因此，根据需要控制镁合金的降解速率仍然很困难，这极大地限制了镁合金作为可降解生物材料的实际应用。本文讨论了基于扩散理论开发的数值模型，该模型可以精确地捕捉镁合金的实验退化行为。然后将数值模型应用到有限元方案中，其中模型使用我们之前关于铸态 Mg-1Ca 和轧制 Mg-3Ge 二元合金腐蚀研究的数据进行校准。使用校准模型来预测针式植入物的退化行为，以证明模型的能力。在实用框架中提供了标准流程，用于获得任何生物医学镁合金的降解行为。通过与大量现有实验结果的比较，进一步验证了该方法。最后，该模型中定义的材料参数作为一种新的材料属性提供。
Magnesium alloys have shown great potential for their use in the medical device field, due to the promising biodegradability. However, it remains a challenge to characterize the degradation behavior of the Mg alloys in a quantitative manner. As such, controlling the degradation rate of the Mg alloys as per our needs is still hard, which greatly limits the practical application of the Mg alloys as a degradable biomaterial. This paper discussed a numerical model developed based on the diffusion theory, which can capture the experimental degradation behavior of the Mg alloys precisely. The numerical model is then implemented into a finite element scheme, where the model is calibrated with the data from our previous studies on the corrosion of the as-cast Mg-1Ca and the as-rolled Mg-3Ge binary alloys. The degradation behavior of a pin implant is predicted using the calibrated model to demonstrate the model’s capability. A standard flow is provided in a practical framework for obtaining the degradation behavior of any biomedical Mg alloys. This methodology was further verifiedviathe comparison with enormous available experimental results. Lastly, the material parameters defined in this model were provided as a new kind of material property.