2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes.
2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes.
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2-氯脱氧腺苷化疗可引发正常和恶性淋巴细胞的程序性细胞死亡。
DOI：
10.1007/978-1-4899-2638-8_3
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发表时间：
1991
影响因子：
--
通讯作者：
Carson,DA
中科院分区：
文献类型：
--
作者：
Carrera,CJ;Piro,LD;Saven,A;Beutler,E;Terai,C;Carson,DA
2-Chloro-2′-deoxyadenosine (CdA) is a congener of deoxyadenosine that is resistant to adenosine deaminase. Rationale for the development of CdA as an immunosuppressive and antineoplastic agent derives from the lymphocytotoxicity of elevated plasma deoxyadenosine in congenital deficiency of adenosine deaminase1. Recent clinical trials have documented promising efficacy of CdA in the treatment of chronic B-cell and T-cell lymphoid malignancies, notably chronic lymphocytic leukemia (CLL) and hairy cell leukemia2,3. Among nucleoside antimetabolites, CdA is uniquely toxic to non-dividing lymphocytes, as well as to most proliferating T-lymphoblasts4. Surprisingly, mature blood monocytes are also lysed by CdA at the nanomolar concentrations readily achieved by continuous infusion in vivo5. In both non-dividing lymphocytes and monocytes, CdA causes the prompt accumulation of DNA strand breaks, with subsequent NAD depletion, inhibition of RNA synthesis, and eventual cell lysis5,6.
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慢性 B 淋巴细胞白血病细胞中 DNA 片段化的诱导。
影响因子：
4.4
作者：
David J. McConkey;M. Aguilar;Pia Hartzell;Ina Eriksson;Håkan Mellstedt;S. Orrenius;Mikael Jondal
通讯作者：
Mikael Jondal
2-氯脱氧腺苷对静止和增殖的人淋巴细胞的特异性毒性
影响因子：
20.3
作者：
D. Carson;D. Wasson;R. Taetle;A. Yu
通讯作者：
A. Yu
伽马射线照射的基因诱导导致淋巴细胞中的 DNA 断裂。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Sellins,KS;Cohen,JJ
通讯作者：
Cohen,JJ
2-氯脱氧腺苷：治疗慢性淋巴细胞白血病的有效新药。
影响因子：
20.3
作者：
Piro,LD;Carrera,CJ;Beutler,E;Carson,DA
通讯作者：
Carson,DA
腺苷、脱氧腺苷和脱氧鸟苷诱导小鼠胸腺细胞中的 DNA 裂解。
影响因子：
4.4
作者：
Harutoshi Kizaki;H. Shimada;F. Ohsaka;T. Sakurada
通讯作者：
T. Sakurada