Proteomic contributions to our understanding of vaccine and immune responses.
Proteomic contributions to our understanding of vaccine and immune responses.
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DOI：
10.1002/prca.201500054
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Link AJ
中科院分区：
文献类型：
--
作者：
Galassie AC;Link AJ
疫苗是最伟大的公共卫生成就之一;然而，由于疫苗设计的经验性质，我们对疫苗诱导的基因和蛋白质如何促进保护性先天和适应性免疫反应的发展没有完全的了解。虽然基因组学的出现使新疫苗的开发和促进免疫反应的理解，蛋白质组学识别潜在的新疫苗抗原的速度和灵敏度不断提高。此外，由于蛋白质组学是转录组学方法的补充，因此两种方法的组合通过系统疫苗学提供了对疫苗接种后免疫应答的更全面的看法。这篇综述详细介绍了蛋白质组学策略在疫苗开发中取得的进展，并回顾了蛋白质组学如何有助于更全面地了解人类疫苗和免疫反应的发展。
Vaccines are one of the greatest public health successes; yet, due to the empirical nature of vaccine design, we have an incomplete understanding of how the genes and proteins induced by vaccines contribute to the development of both protective innate and adaptive immune responses. While the advent of genomics has enabled new vaccine development and facilitated understanding of the immune response, proteomics identifies potentially new vaccine antigens with increasing speed and sensitivity. In addition, as proteomics is complementary to transcriptomic approaches, a combination of both approaches provides a more comprehensive view of the immune response after vaccination via systems vaccinology. This review details the advances that proteomic strategies have made in vaccine development and reviews how proteomics contributes to the development of a more complete understanding of human vaccines and immune responses.